دورية أكاديمية
An atypical pattern of Epstein-Barr virus infection in a case with idiopathic tubulointerstitial nephritis.
| العنوان: | An atypical pattern of Epstein-Barr virus infection in a case with idiopathic tubulointerstitial nephritis. |
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| المؤلفون: | Okada H; Department of Nephrology, Saitama Medical College, 38 Morohongo, Moroyama-machi, Irumagun, Saitama 350-04, Japan., Ikeda N, Kobayashi T, Inoue T, Kanno Y, Sugahara S, Nakamoto H, Yamamoto T, Suzuki H |
| المصدر: | Nephron [Nephron] 2002 Oct; Vol. 92 (2), pp. 440-4. |
| نوع المنشور: | Case Reports; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Karger Country of Publication: Switzerland NLM ID: 0331777 Publication Model: Print Cited Medium: Print ISSN: 1660-8151 (Print) Linking ISSN: 16608151 NLM ISO Abbreviation: Nephron Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Basel ; New York : Karger |
| مواضيع طبية MeSH: | Epstein-Barr Virus Infections/*etiology , Nephritis, Interstitial/*etiology, Acute Kidney Injury/etiology ; Acute Kidney Injury/pathology ; Acute Kidney Injury/virology ; Aged ; Herpesvirus 4, Human/isolation & purification ; Humans ; Kidney/pathology ; Kidney/virology ; Male ; Nephritis, Interstitial/pathology ; Nephritis, Interstitial/virology ; Nephrosis, Lipoid/etiology ; Nephrosis, Lipoid/pathology ; Nephrosis, Lipoid/virology ; T-Lymphocytes/pathology ; T-Lymphocytes/virology |
| مستخلص: | Recently, Epstein-Barr virus (EBV) received attention because a latent form of its infection in renal proximal tubular epithelial cells was found to cause idiopathic, chronic tubulointerstitial nephritis. In this report, we describe the case of a patient with a replicative form of EBV infection, chronic active EBV infection (CAEBV), who developed acute tubulointerstitial nephritis and minimal change nephrotic syndrome. A renal biopsy revealed papillary infoldings of atypical tubular epithelium and adjacent dense infiltration of lymphocytes. Using in situ polymerase chain reaction methods, we detected the EBV genome in some of the infiltrating lymphocytes, but not in the tubular epithelial cells. EBV-infected T cells are thought to activate other educated T cells, as well as secrete an unrestricted variety of cytokines, thus playing a pivotal role in CAEBV and its end organ disease. Therefore, in our case, the CAEBV activated, educated T cells may have followed the EBV-infected lymphocytes as they infiltrated into the peritubular interstitium, and promoted focal tubular epithelial atypia and minimal change nephrotic syndrome. The long-term observation of such patients is important because CAEBV may progress into lymphoproliferative diseases. (Copyright 2002 S. Karger AG, Basel) |
| تواريخ الأحداث: | Date Created: 20020910 Date Completed: 20030303 Latest Revision: 20171101 |
| رمز التحديث: | 20240627 |
| DOI: | 10.1159/000063322 |
| PMID: | 12218326 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1660-8151 |
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| DOI: | 10.1159/000063322 |