دورية أكاديمية
Cardiovascular effects of Urtica dioica L. in isolated rat heart and aorta.
| العنوان: | Cardiovascular effects of Urtica dioica L. in isolated rat heart and aorta. |
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| المؤلفون: | Legssyer A; Laboratoire de Physiologie et Pharmacologie Cellulaire, Département de Biologie, Facultédes Sciences, Université Mohamed Premier, BP 524, 60000 Oujda, Maroc. alegssyer@sciences.univ-oujda.ac.ma, Ziyyat A, Mekhfi H, Bnouham M, Tahri A, Serhrouchni M, Hoerter J, Fischmeister R |
| المصدر: | Phytotherapy research : PTR [Phytother Res] 2002 Sep; Vol. 16 (6), pp. 503-7. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley Country of Publication: England NLM ID: 8904486 Publication Model: Print Cited Medium: Print ISSN: 0951-418X (Print) Linking ISSN: 0951418X NLM ISO Abbreviation: Phytother Res Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Original Publication: London : Heyden & Son, c1987- |
| مواضيع طبية MeSH: | Urtica dioica*, Aorta, Thoracic/*drug effects , Heart Rate/*drug effects , Plant Extracts/*pharmacology, Adrenergic alpha-Agonists/pharmacology ; Adrenergic alpha-Antagonists/pharmacology ; Animals ; Aorta, Thoracic/physiology ; Atropine/pharmacology ; Blood Pressure/drug effects ; Carbachol/pharmacology ; Drug Interactions ; In Vitro Techniques ; Male ; Muscarinic Antagonists/pharmacology ; Norepinephrine/pharmacology ; Prazosin/pharmacology ; Rats ; Rats, Wistar ; Vasoconstriction/drug effects |
| مستخلص: | Urtica dioica L. or Nettle (Urticaceae) is widely used in oriental Morocco to treat hypertension. Aqueous extract of Nettle (AEN) also exerts a hypotensive action in the rat in vivo. The aim of this work was to characterize the specific cardiac and vascular effects of AEN. In the isolated Langendorff perfused rat heart, AEN (1 and 2 g/l) markedly decreased heart rate and increased left ventricular pressure. Higher concentration (5 g/l) even led to cardiac arrest. Although carbachol mimicked the bradycardiac effect of AEN, atropine (a muscarinic receptor antagonist, 1 micro M) did not modify the response. Beside its action on myocardium, AEN also affected vascular contractility. Indeed, AEN (0.1-5 g/l) produced a dose-dependent increase in basal tone of isolated rat aorta. This effect was endothelium independent and was abolished by 1 micro M prazosin (an alpha1-adrenergic antagonist). AEN had little additional effects when the aorta was precontracted by noradrenaline (1 micro M) or KCl (40 mM). Our data indicate that AEN produces a vasoconstriction of the aorta which is due to activation of alpha1-adrenergic receptors. However, AEN also induces a strong bradycardia through non-cholinergic and non-adrenergic pathways which might compensate for its vascular effect and account for the hypotensive action of Urtica dioica L described in vivo. (Copyright 2002 John Wiley & Sons, Ltd.) |
| المشرفين على المادة: | 0 (Adrenergic alpha-Agonists) 0 (Adrenergic alpha-Antagonists) 0 (Muscarinic Antagonists) 0 (Plant Extracts) 7C0697DR9I (Atropine) 8Y164V895Y (Carbachol) X4W3ENH1CV (Norepinephrine) XM03YJ541D (Prazosin) |
| تواريخ الأحداث: | Date Created: 20020919 Date Completed: 20021209 Latest Revision: 20151119 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1002/ptr.1087 |
| PMID: | 12237804 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0951-418X |
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| DOI: | 10.1002/ptr.1087 |