دورية أكاديمية
CD5+ follicular lymphoma: a clinicopathologic study of three cases.
| العنوان: | CD5+ follicular lymphoma: a clinicopathologic study of three cases. |
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| المؤلفون: | Barry TS; Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA., Jaffe ES, Kingma DW, Martin AW, Sorbara L, Raffeld M, Pittaluga S |
| المصدر: | American journal of clinical pathology [Am J Clin Pathol] 2002 Oct; Vol. 118 (4), pp. 589-98. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 0370470 Publication Model: Print Cited Medium: Print ISSN: 0002-9173 (Print) Linking ISSN: 00029173 NLM ISO Abbreviation: Am J Clin Pathol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2016- : Oxford : Oxford University Press Original Publication: Philadelphia [etc.] Lippincott [etc.] |
| مواضيع طبية MeSH: | CD5 Antigens/*metabolism , Lymphoma, Follicular/*metabolism , Lymphoma, Follicular/*pathology, Adult ; B-Lymphocytes/metabolism ; B-Lymphocytes/pathology ; Chromosomes, Human, Pair 14 ; Chromosomes, Human, Pair 18 ; DNA, Neoplasm/analysis ; DNA-Binding Proteins/metabolism ; Female ; Flow Cytometry ; Gene Rearrangement, B-Lymphocyte, Heavy Chain ; Humans ; Immunoglobulin Light Chains/metabolism ; Lymphoma, Follicular/genetics ; Male ; Middle Aged ; Neprilysin/metabolism ; Proto-Oncogene Proteins/metabolism ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Proto-Oncogene Proteins c-bcl-6 ; Transcription Factors/metabolism ; Translocation, Genetic |
| مستخلص: | Follicular lymphoma (FL) is a low-grade lymphoma that typically lacks CD5 antigen expression. We report 3 cases of FL with unusual expression of CD5. All cases showed histologic features of FL, including effaced nodal architecture, follicular growth pattern, and a spectrum of grades from 1 to 3 using World Health Organization criteria. In flow cytometric studies, all 3 cases showed a light chain-restricted, CD19+, CD20+ B-cell population coexpressing CD10 and low-level CD5. Immunohistochemical studies demonstrated an identical B-cell immunophenotype with weak expression of CD5 and coexpression of bcl-2 protein and the germinal center-associated markers, CD10 and bcl-6 protein. None of the cases showed expression of CD43, cyclin D1, or IgD. By molecular analysis, immunoglobulin heavy chain gene rearrangements were demonstrated in all 3 cases, and 2 of 3 cases had a t(14;18). These cases highlight the difficulty classifying these lymphomas by flow cytometric studies alone and emphasize the importance of recognizing FL in the differential diagnosis of CD5+ B-cell lymphomas. |
| المشرفين على المادة: | 0 (CD5 Antigens) 0 (DNA, Neoplasm) 0 (DNA-Binding Proteins) 0 (Immunoglobulin Light Chains) 0 (Proto-Oncogene Proteins) 0 (Proto-Oncogene Proteins c-bcl-2) 0 (Proto-Oncogene Proteins c-bcl-6) 0 (Transcription Factors) EC 3.4.24.11 (Neprilysin) |
| تواريخ الأحداث: | Date Created: 20021012 Date Completed: 20021024 Latest Revision: 20171116 |
| رمز التحديث: | 20240627 |
| DOI: | 10.1309/4KEH-AGY7-UT5H-41XJ |
| PMID: | 12375647 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0002-9173 |
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| DOI: | 10.1309/4KEH-AGY7-UT5H-41XJ |