دورية أكاديمية
Antifungal drug susceptibility of Candida albicans.
| العنوان: | Antifungal drug susceptibility of Candida albicans. |
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| المؤلفون: | Bii CC; Centre for Microbiology Research, Kenya Medical Research Institute, Nairobi., Ouko TT, Amukoye E, Githinji LW |
| المصدر: | East African medical journal [East Afr Med J] 2002 Mar; Vol. 79 (3), pp. 143-5. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Medical Association of East Africa Country of Publication: Kenya NLM ID: 0372766 Publication Model: Print Cited Medium: Print ISSN: 0012-835X (Print) Linking ISSN: 0012835X NLM ISO Abbreviation: East Afr Med J Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Nairobi Medical Association of East Africa |
| مواضيع طبية MeSH: | Antifungal Agents/*pharmacokinetics , Candida albicans/*drug effects, Adult ; Candida albicans/isolation & purification ; Child, Preschool ; Humans ; In Vitro Techniques ; Microbial Sensitivity Tests |
| مستخلص: | Objective: To determine the susceptibility of clinical isolates of Candida albicans and to establish the minimum inhibitory concentrations (MIC) to commonly used antifungal drugs. Design: Laboratory based experiment. Setting: Mbagathi District Hospital, Nairobi, Kenya. Subjects: Candida albicans isolated between 1998 and 2000 from the sputa of HIV/AIDS patients and throat swabs of children with acute respiratory infections (ARI). Methods: Susceptibility to amphotericin B, clotrimazole, nystatin, and 5-fluorocytosine was done using agar dilution method (NCCLS 1997). Results: Among the ARI isolates 29.3% and among HIV isolates 22.4% had MIC>0.5 microg/ml to amphotericin B. Over 80% of the ARI isolates had MICs > 1 microg/ml to clotrimazole. The MIC range of most isolates to nystatin was 4-16 microg/ml while most isolates were susceptible to 5-fluorocytosine. There were no significant differences in susceptibility between ARI and HIV isolates to commonly used antifungal drugs. Conclusion: Although fungal resistance has not been extensively studied, susceptibility tests showed some Candida albicans have increased MICs to commonly used antifungal drugs. The results call for further investigations on fungal resistance especially in the context of opportunistic infections in HIV/AIDS. |
| المشرفين على المادة: | 0 (Antifungal Agents) |
| تواريخ الأحداث: | Date Created: 20021023 Date Completed: 20021106 Latest Revision: 20190922 |
| رمز التحديث: | 20231215 |
| DOI: | 10.4314/eamj.v79i3.8894 |
| PMID: | 12389961 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0012-835X |
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| DOI: | 10.4314/eamj.v79i3.8894 |