دورية أكاديمية
أعرض في EDS

Antiproliferative effects of a non-beta-oxidizable fatty acid, tetradecylthioacetic acid, in native human acute myelogenous leukemia blast cultures.

التفاصيل البيبلوغرافية
العنوان: Antiproliferative effects of a non-beta-oxidizable fatty acid, tetradecylthioacetic acid, in native human acute myelogenous leukemia blast cultures.
المؤلفون: Tronstad KJ; Department of Clinical Biochemistry, University of Bergen, Haukeland University Hospital, Norway., Bruserud Ø, Berge K, Berge RK
المصدر: Leukemia [Leukemia] 2002 Nov; Vol. 16 (11), pp. 2292-301.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group, Specialist Journals Country of Publication: England NLM ID: 8704895 Publication Model: Print Cited Medium: Print ISSN: 0887-6924 (Print) Linking ISSN: 08876924 NLM ISO Abbreviation: Leukemia Subsets: MEDLINE
أسماء مطبوعة: Publication: 2000- : London : Nature Publishing Group, Specialist Journals
Original Publication: [Baltimore, Md.] : Williams & Wilkins, [c1987-
مواضيع طبية MeSH: Antioxidants/*pharmacology , Cell Division/*drug effects , Cytokines/*metabolism , Enzyme Inhibitors/*pharmacology , Leukemia, Myeloid/*pathology , Palmitic Acid/*pharmacology , Sulfides/*pharmacology, Acute Disease ; Adult ; Aged ; Aged, 80 and over ; Blast Crisis/pathology ; Blood Cell Count ; Carnitine O-Palmitoyltransferase/metabolism ; Female ; Glutathione/metabolism ; Humans ; Interleukin-1/metabolism ; Interleukin-6/metabolism ; Leukemia, Myeloid/drug therapy ; Leukemia, Myeloid/metabolism ; Lymphocyte Activation/drug effects ; Male ; Middle Aged ; Oxidation-Reduction ; Oxidoreductases/metabolism ; Superoxide Dismutase/metabolism ; Tumor Cells, Cultured ; Tumor Necrosis Factor-alpha/metabolism
مستخلص: The lipid metabolism is important in the regulation of cell proliferation. We have examined effects of a fatty acid analogue, tetradecylthioacetic acid (TTA), on the functional phenotype of native, human AML cells. TTA inhibited AML blast proliferation in the presence of single cytokines (GM-CSF and SCF: P > 0.05, 35 patients with detectable proliferation) and a combination of cytokines (P < 0.005, n = 21). This antiproliferative effect was generally stronger than for the normal fatty acid palmitic acid (PA). Both TTA and PA increased the secretion of tumor necrosis factor alpha (TNFalpha) (P < 0.05, 27 patients with detectable cytokine release), but only PA increased interleukein 1beta (IL-1beta) release (P < 0.005, n = 34). AML blast populations varied significantly in their levels and activities of metabolites and enzymes characterizing oxidative status and fatty acid metabolism, and there was no significant correlation between the intrinsic oxidative status and the effects of PA and TTA on blast proliferation. Although TTA reduced the proliferation of mitogen-stimulated normal T cells derived from healthy individuals (P < 0.05, n = 8), no adverse effects were seen on peripheral blood cell counts (reticulocytes, platelets, total white blood cells, differential leukocyte counts) for healthy volunteers receiving TTA (oral administration of 1000 mg/day for 7 consecutive days). Our results suggest that TTA can inhibit AML blast proliferation through pathways that are unrelated to autocrine cytokine secretion and intrinsic oxidative status.
المشرفين على المادة: 0 (Antioxidants)
0 (Cytokines)
0 (Enzyme Inhibitors)
0 (Interleukin-1)
0 (Interleukin-6)
0 (Sulfides)
0 (Tumor Necrosis Factor-alpha)
2V16EO95H1 (Palmitic Acid)
7ZU5I25S2O (1-(carboxymethylthio)tetradecane)
EC 1.- (Oxidoreductases)
EC 1.15.1.1 (Superoxide Dismutase)
EC 1.3.3.- (acyl CoA oxidase 3)
EC 2.3.1.21 (Carnitine O-Palmitoyltransferase)
GAN16C9B8O (Glutathione)
تواريخ الأحداث: Date Created: 20021026 Date Completed: 20021202 Latest Revision: 20171116
رمز التحديث: 20221213
DOI: 10.1038/sj.leu.2402698
PMID: 12399975
قاعدة البيانات: MEDLINE
الوصف
تدمد:0887-6924
DOI:10.1038/sj.leu.2402698