دورية أكاديمية
A potential role of macrophage activation in the treatment of cancer.
| العنوان: | A potential role of macrophage activation in the treatment of cancer. |
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| المؤلفون: | Klimp AH; Department of Physiological Chemistry, Faculty of Medical Sciences, Groningen University Institute for Drug Exploration, University of Groningen, A. Deusinglaan 1, 9713 AV, Groningen, The Netherlands. a.h.klimp@med.rug.nl, de Vries EG, Scherphof GL, Daemen T |
| المصدر: | Critical reviews in oncology/hematology [Crit Rev Oncol Hematol] 2002 Nov; Vol. 44 (2), pp. 143-61. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Scientific Publishers Country of Publication: Netherlands NLM ID: 8916049 Publication Model: Print Cited Medium: Print ISSN: 1040-8428 (Print) Linking ISSN: 10408428 NLM ISO Abbreviation: Crit Rev Oncol Hematol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2005->: Amsterdam : Elsevier Scientific Publishers Original Publication: Boca Raton, Fla. : CRC Press, 1983- |
| مواضيع طبية MeSH: | Immunotherapy*, Macrophages/*immunology , Neoplasms/*therapy, Animals ; Cytotoxicity, Immunologic ; Dendritic Cells/immunology ; Humans ; Macrophages/metabolism |
| مستخلص: | One of the functions of macrophages is to provide a defense mechanism against tumor cells. In the last decades the mechanism of tumor cell killing by macrophages have been studied extensively. The tumor cytotoxic function of macrophages requires stimulation either with bacterial cell wall products such as lipopolysaccharide (LPS) or muramyldipeptide (MDP) or with cytokines such as interferon-gamma (IFN-gamma) and granulocyte-macrophage colony-stimulating factor (GM-CSF). Activated macrophages secrete several substances that are directly involved in tumor cell killing i.e. tumor necrosis factor (TNF) and nitric oxide (NO). On the other hand, substances are secreted that are able to stimulate tumor cell growth, depending on the stage and the nature of the tumor. Several clinical trials have been performed aiming at the activation of macrophages or dendritic cells, a subpopulation of the macrophages. In this review we will summarize and discuss experimental studies and clinical trials based on the activation of macrophages. |
| Number of References: | 223 |
| تواريخ الأحداث: | Date Created: 20021105 Date Completed: 20030702 Latest Revision: 20201212 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/s1040-8428(01)00203-7 |
| PMID: | 12413632 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1040-8428 |
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| DOI: | 10.1016/s1040-8428(01)00203-7 |