دورية أكاديمية
In vitro and in vivo degradation of bioabsorbable PLLA spinal fusion cages.
| العنوان: | In vitro and in vivo degradation of bioabsorbable PLLA spinal fusion cages. |
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| المؤلفون: | van Dijk M; Department of Orthopaedic Surgery, Vrije Universiteit Medical Center, Amsterdam, The Netherlands., Tunc DC, Smit TH, Higham P, Burger EH, Wuisman PI |
| المصدر: | Journal of biomedical materials research [J Biomed Mater Res] 2002; Vol. 63 (6), pp. 752-9. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley Country of Publication: United States NLM ID: 0112726 Publication Model: Print Cited Medium: Print ISSN: 0021-9304 (Print) Linking ISSN: 00219304 NLM ISO Abbreviation: J Biomed Mater Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Hoboken, N.J. [etc.] Wiley. |
| مواضيع طبية MeSH: | Diffusion Chambers, Culture*, Biocompatible Materials/*metabolism , Lactic Acid/*metabolism , Polymers/*metabolism , Spinal Fusion/*instrumentation, Absorption ; Animals ; Biodegradation, Environmental ; Female ; Goats ; In Vitro Techniques ; Lumbar Vertebrae/surgery ; Materials Testing ; Models, Animal ; Polyesters ; Time Factors |
| مستخلص: | The in vitro and in vivo degradation of poly-L-lactic acid cages used as an adjunct to spinal arthrodesis was investigated. In the in vitro experiments cages were subjected to aging up to 73 weeks in phosphate-buffered solution (pH 7.4) at 37 degrees C. Inherent viscosity, crystallinity, and mechanical strength were determined at different time points. In the in vivo study, the poly-L-lactic acid cages were packed with bone graft and implanted in the L3-L4 spinal motion segment of 18 Dutch milk goats. At 12, 26, and 52 weeks, the motion segments were isolated and poly-L-lactic acid samples retrieved. On evaluation, the in vivo implanted cages showed an advanced decline in inherent viscosity compared to the cages subjected to in vitro degradation experiments. At 6 months of implantation, the geometrical shape and original height of 10 mm was maintained during 6 months of follow up. This finding fits well with the observation that mechanical strength was maintained for a period of 6 months in vitro. At 12 months, the poly-L-lactic acid cage had been disintegrated into multiple fragments with signs of absorption. Despite the high-load-bearing conditions, the poly-L-lactic acid cage allowed interbody fusion to occur without collapse of the cage. (Copyright 2002 Wiley Periodicals, Inc.) |
| المشرفين على المادة: | 0 (Biocompatible Materials) 0 (Polyesters) 0 (Polymers) 33X04XA5AT (Lactic Acid) 459TN2L5F5 (poly(lactide)) |
| تواريخ الأحداث: | Date Created: 20021106 Date Completed: 20030613 Latest Revision: 20220330 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1002/jbm.10466 |
| PMID: | 12418020 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0021-9304 |
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| DOI: | 10.1002/jbm.10466 |