دورية أكاديمية
Randomized study to evaluate the use of high-dose therapy as part of primary treatment for "aggressive" lymphoma.
| العنوان: | Randomized study to evaluate the use of high-dose therapy as part of primary treatment for "aggressive" lymphoma. |
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| المؤلفون: | Kaiser U; Department of Hematology, Universitätsklinikum Marburg, Germany. pd.dr.u.kaiser@bernward-khs.de, Uebelacker I, Abel U, Birkmann J, Trümper L, Schmalenberg H, Karakas T, Metzner B, Hossfeld DK, Bischoff HG, Franke A, Reiser M, Müller P, Mantovani L, Grundeis M, Rothmann F, von Seydewitz CU, Mesters RM, Steinhauer EU, Krahl D, Schumacher K, Kneba M, Baudis M, Schmitz N, Pfab R, Köppler H, Parwaresch R, Pfreundschuh M, Havemann K |
| المصدر: | Journal of clinical oncology : official journal of the American Society of Clinical Oncology [J Clin Oncol] 2002 Nov 15; Vol. 20 (22), pp. 4413-9. |
| نوع المنشور: | Clinical Trial; Clinical Trial, Phase III; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Society of Clinical Oncology Country of Publication: United States NLM ID: 8309333 Publication Model: Print Cited Medium: Print ISSN: 0732-183X (Print) Linking ISSN: 0732183X NLM ISO Abbreviation: J Clin Oncol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2003- : Alexandria, VA : American Society of Clinical Oncology Original Publication: New York, N.Y. : Grune & Stratton, c1983- |
| مواضيع طبية MeSH: | Stem Cell Transplantation*, Antineoplastic Combined Chemotherapy Protocols/*therapeutic use , L-Lactate Dehydrogenase/*blood , Lymphoma, Non-Hodgkin/*enzymology , Lymphoma, Non-Hodgkin/*therapy, Antineoplastic Combined Chemotherapy Protocols/administration & dosage ; Carmustine/administration & dosage ; Chemotherapy, Adjuvant ; Cyclophosphamide/administration & dosage ; Cytarabine/administration & dosage ; Doxorubicin/administration & dosage ; Drug Administration Schedule ; Etoposide/administration & dosage ; Female ; Germany ; Humans ; Lymphoma, Non-Hodgkin/drug therapy ; Lymphoma, Non-Hodgkin/radiotherapy ; Male ; Melphalan/administration & dosage ; Middle Aged ; Prednisolone/administration & dosage ; Prognosis ; Prospective Studies ; Radiotherapy, Adjuvant ; Risk ; Survival Analysis ; Transplantation, Autologous ; Treatment Outcome ; Vincristine/administration & dosage |
| مستخلص: | Purpose: This trial of the German High-Grade Non-Hodgkin's Lymphoma Study Group compares the use of high-dose therapy (HDT) as part of primary treatment with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) plus etoposide followed by involved-field (IF) radiotherapy in a randomized, multicenter, phase III study. Patients and Methods: Three hundred twelve patients with "aggressive" non-Hodgkin's lymphoma aged Conclusion: Results of the randomized trial comparing CHOP-like chemotherapy with early HDT do not support the use of HDT with carmustine, etoposide, cytarabine, and melphalan following shortened standard chemotherapy. |
| التعليقات: | Comment in: J Clin Oncol. 2002 Nov 15;20(22):4411-2. (PMID: 12431961) Comment in: Cancer Treat Rev. 2003 Apr;29(2):139-42. (PMID: 12670459) |
| المشرفين على المادة: | 04079A1RDZ (Cytarabine) 5J49Q6B70F (Vincristine) 6PLQ3CP4P3 (Etoposide) 80168379AG (Doxorubicin) 8N3DW7272P (Cyclophosphamide) 9PHQ9Y1OLM (Prednisolone) EC 1.1.1.27 (L-Lactate Dehydrogenase) Q41OR9510P (Melphalan) U68WG3173Y (Carmustine) |
| SCR Protocol: | BEAM regimen; CHOEP protocol |
| تواريخ الأحداث: | Date Created: 20021115 Date Completed: 20030221 Latest Revision: 20161102 |
| رمز التحديث: | 20240627 |
| DOI: | 10.1200/JCO.2002.07.075 |
| PMID: | 12431962 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0732-183X |
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| DOI: | 10.1200/JCO.2002.07.075 |