دورية أكاديمية
Synthetic metabolites of neurohypophyseal hormones. (Des-9-glycinamide)oxytocin and (des-9-glycinamide, des-8-leucine)oxytocin.
| العنوان: | Synthetic metabolites of neurohypophyseal hormones. (Des-9-glycinamide)oxytocin and (des-9-glycinamide, des-8-leucine)oxytocin. |
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| المؤلفون: | Walter R, Havran RT, Schwartz IL |
| المصدر: | Journal of medicinal chemistry [J Med Chem] 1976 Feb; Vol. 19 (2), pp. 328-30. |
| نوع المنشور: | Journal Article; Research Support, U.S. Gov't, P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print Cited Medium: Print ISSN: 0022-2623 (Print) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Washington Dc : American Chemical Society Original Publication: [Easton, Pa.] : American Chemical Society, [c1963- |
| مواضيع طبية MeSH: | Oxytocin/*analogs & derivatives , Pituitary Hormones, Posterior/*metabolism, Animals ; Anura ; Biological Transport/drug effects ; Blood Pressure/drug effects ; Body Water/metabolism ; Chickens ; Diuresis/drug effects ; Female ; In Vitro Techniques ; Male ; Osmosis/drug effects ; Oxytocin/chemical synthesis ; Oxytocin/pharmacology ; Rats ; Urinary Bladder/metabolism ; Uterine Contraction/drug effects |
| مستخلص: | Syntheses and biological properties are reported for two analogs of oxytocin in which the glycinamide and the leucylglycinamide moiety, respectively, have been deleted from the parent hormone. Both [des-9-glycinamide]oxytocin and [des-9-glycinamide,des-8-leucine]oxytocin are weak agonists in the rat uterotonic and antidiuretic assays but possess no detectable rat pressor activity. In addition, [des-9-glycinamide]oxytocin is an inhibitor of the oxytocin-induced vasodepressor response in fowl but is a potent agonist in the hydroosmotic assay of the toad urinary bladder. |
| المشرفين على المادة: | 0 (Pituitary Hormones, Posterior) 50-56-6 (Oxytocin) |
| تواريخ الأحداث: | Date Created: 19760201 Date Completed: 19760429 Latest Revision: 20190709 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1021/jm00224a025 |
| PMID: | 1249815 |
| قاعدة البيانات: | MEDLINE |
Find this issue from the American Chemical Society | تدمد: | 0022-2623 |
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| DOI: | 10.1021/jm00224a025 |