دورية أكاديمية
Potassium-dependent sodium-calcium exchange through the eye of the fly.
| العنوان: | Potassium-dependent sodium-calcium exchange through the eye of the fly. |
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| المؤلفون: | Webel R; Department of Ophthalmology & Visual Science, University of Wisconsin, Madison, Wisconsin 53792, USA., Haug-Collet K, Pearson B, Szerencsei RT, Winkfein RJ, Schnetkamp PP, Colley NJ |
| المصدر: | Annals of the New York Academy of Sciences [Ann N Y Acad Sci] 2002 Nov; Vol. 976, pp. 300-14. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: New York Academy of Sciences Country of Publication: United States NLM ID: 7506858 Publication Model: Print Cited Medium: Print ISSN: 0077-8923 (Print) Linking ISSN: 00778923 NLM ISO Abbreviation: Ann N Y Acad Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2006- : New York, NY : Malden, MA : New York Academy of Sciences ; Blackwell Original Publication: New York, The Academy. |
| مواضيع طبية MeSH: | Ocular Physiological Phenomena*, Sodium-Calcium Exchanger/*chemistry , Sodium-Calcium Exchanger/*physiology, Amino Acid Sequence ; Animals ; Darkness ; Drosophila ; Kinetics ; Light ; Molecular Sequence Data ; Sequence Alignment ; Sequence Homology, Amino Acid |
| مستخلص: | In this review, we describe the characterization of a Drosophila sodium/calcium-potassium exchanger, Nckx30C. Sodium/calcium (-potassium) exchangers (NCX and NCKX) are required for the rapid removal of calcium in excitable cells. The deduced protein topology for NCKX30C is similar to that of mammalian NCKX, with 5 hydrophobic domains in the amino terminus separated from 6 at the carboxy-terminal end by a large intracellular loop. NCKX30C functions as a potassium-dependent sodium-calcium exchanger and is expressed in adult neurons and during ventral nerve cord development in the embryo. Nckx30C is expressed in a dorsal/ventral pattern in the eye-antennal disc, suggesting that large fluxes of calcium may be occurring during imaginal disc development in the larvae. NCKX30C may play a critical role in modulating calcium during development as well as in the removal of calcium and maintenance of calcium homeostasis in adults. |
| Number of References: | 74 |
| معلومات مُعتمدة: | R01 EY008768 United States EY NEI NIH HHS; EY08768 United States EY NEI NIH HHS |
| المشرفين على المادة: | 0 (Sodium-Calcium Exchanger) 147478-17-9 (potassium-dependent sodium-calcium exchanger) |
| تواريخ الأحداث: | Date Created: 20021228 Date Completed: 20030403 Latest Revision: 20190616 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1111/j.1749-6632.2002.tb04753.x |
| PMID: | 12502573 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0077-8923 |
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| DOI: | 10.1111/j.1749-6632.2002.tb04753.x |