دورية أكاديمية
A comparison of the antinociceptive effects of voltage-activated Na+ channel blockers in two rat models of neuropathic pain.
| العنوان: | A comparison of the antinociceptive effects of voltage-activated Na+ channel blockers in two rat models of neuropathic pain. |
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| المؤلفون: | Erichsen HK; Department of Pharmacology, NeuroSearch A/S, 93 Pederstrupvej, DK-2750, Ballerup, Denmark., Hao JX, Xu XJ, Blackburn-Munro G |
| المصدر: | European journal of pharmacology [Eur J Pharmacol] 2003 Jan 05; Vol. 458 (3), pp. 275-82. |
| نوع المنشور: | Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print Cited Medium: Print ISSN: 0014-2999 (Print) Linking ISSN: 00142999 NLM ISO Abbreviation: Eur J Pharmacol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2005- : Amsterdam : Elsevier Science Original Publication: Amsterdam, North Holland Pub. Co. |
| مواضيع طبية MeSH: | Analgesics/*pharmacology , Neuralgia/*prevention & control , Sodium Channel Blockers/*pharmacology, Analysis of Variance ; Anesthetics, Local/pharmacology ; Animals ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Hindlimb/drug effects ; Hindlimb/injuries ; Hindlimb/innervation ; Lamotrigine ; Lidocaine/pharmacology ; Male ; Mexiletine/pharmacology ; Pain Measurement/methods ; Rats ; Rats, Sprague-Dawley ; Sodium Channels/drug effects ; Time Factors ; Tocainide/pharmacology ; Triazines/pharmacology |
| مستخلص: | The pain-relieving effects of various voltage-activated Na(+) channel blockers have been evaluated in two rat models of neuropathic pain; the photochemically induced nerve injury model (Gazelius) and spared nerve injury model. Lidocaine (up to 40 mg/kg, i.p.) and lamotrigine (up to 60 mg/kg, i.p.) had no effect on mechanical or cold allodynia in either model. However, lamotrigine (10, 30 and 60 mg/kg) significantly attenuated mechanical hyperalgesia in the spared nerve injury model, while mexiletine (25 and 37.5 mg/kg, i.p.) attenuated mechanical allodynia in the Gazelius model. Tocainide (50, 75 and 100 mg/kg, i.p.) significantly reduced all types of pain behaviour measured. The present results show that these voltage-activated Na(+) channel blockers have broadly similar antinociceptive effects in these two models of neuropathic pain. They also show that these drugs can have markedly different effects on distinct neuropathic pain-related behaviours within models. |
| المشرفين على المادة: | 0 (Analgesics) 0 (Anesthetics, Local) 0 (Sodium Channel Blockers) 0 (Sodium Channels) 0 (Triazines) 1U511HHV4Z (Mexiletine) 27DXO59SAN (Tocainide) 98PI200987 (Lidocaine) U3H27498KS (Lamotrigine) |
| تواريخ الأحداث: | Date Created: 20021231 Date Completed: 20030520 Latest Revision: 20190624 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/s0014-2999(02)02792-9 |
| PMID: | 12504783 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0014-2999 |
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| DOI: | 10.1016/s0014-2999(02)02792-9 |