دورية أكاديمية
Accuracy of fetal growth indicators as surrogate measures of steroid hormone levels during pregnancy.
| العنوان: | Accuracy of fetal growth indicators as surrogate measures of steroid hormone levels during pregnancy. |
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| المؤلفون: | Peck JD; Department of Epidemiology, University of North Carolina School of Public Health, Chapel Hill, NC, USA. jdpeck@srph.tamushsc.edu, Hulka BS, Savitz DA, Baird D, Poole C, Richardson BE |
| المصدر: | American journal of epidemiology [Am J Epidemiol] 2003 Feb 01; Vol. 157 (3), pp. 258-66. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: United States NLM ID: 7910653 Publication Model: Print Cited Medium: Print ISSN: 0002-9262 (Print) Linking ISSN: 00029262 NLM ISO Abbreviation: Am J Epidemiol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Cary, NC : Oxford University Press Original Publication: Baltimore, School of Hygiene and Public Health of Johns Hopkins Univ. |
| مواضيع طبية MeSH: | Birth Weight*, Estrogens/*blood, Biomarkers ; Case-Control Studies ; Female ; Humans ; Infant, Newborn ; Logistic Models ; Pregnancy ; ROC Curve |
| مستخلص: | This study evaluates the use of fetal growth characteristics as surrogate measures for steroid hormone exposures during pregnancy. The validity of using birth weight, birth length, ponderal index, and placental weight as indicators of pregnancy hormone exposures was assessed using third-trimester serum samples from 568 pregnant women who participated in the Child Health and Development Studies, Berkeley, California (1959-1966). The magnitude of the associations between birth characteristics and hormone concentrations was assessed using geometric means, Pearson's correlations, and linear and logistic regression. Accuracy was evaluated using sensitivity, specificity, and receiver operating characteristic curve analyses. The strongest and most consistent association observed was between birth weight and estriol levels. Despite a positive correlation (r = 0.32) and strong associations with high estriol levels (odds ratio for highest compared with lowest birth weight quartile = 6.63, 95% confidence interval: 3.20, 12.5), the predictive performance of birth weight as a proxy for estriol levels was poor (area under the receiver operating characteristic curve = 0.66, 95% confidence interval: 0.61, 0.71). Likewise, all fetal growth measures revealed little discriminatory ability as indicators of estriol, estrone, estradiol, or progesterone levels. Thus, observed associations with these surrogate measures may not be a reflection of pregnancy hormone exposure and should be interpreted with caution. |
| معلومات مُعتمدة: | N01HD63258 United States HD NICHD NIH HHS; R03 CA 75953 United States CA NCI NIH HHS |
| المشرفين على المادة: | 0 (Biomarkers) 0 (Estrogens) |
| تواريخ الأحداث: | Date Created: 20030125 Date Completed: 20030211 Latest Revision: 20190513 |
| رمز التحديث: | 20240627 |
| DOI: | 10.1093/aje/kwf183 |
| PMID: | 12543626 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0002-9262 |
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| DOI: | 10.1093/aje/kwf183 |