دورية أكاديمية
Comparative genomic hybridization analysis of craniopharyngiomas.
العنوان: | Comparative genomic hybridization analysis of craniopharyngiomas. |
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المؤلفون: | Rienstein S; Danek Gertner Institute of Genetics, Susanne Levy Gertner Oncogenetics Unit, and Chaim Sheba Medical Center, Tel-Hashomer, Israel., Adams EF, Pilzer D, Goldring AA, Goldman B, Friedman E |
المصدر: | Journal of neurosurgery [J Neurosurg] 2003 Jan; Vol. 98 (1), pp. 162-4. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: American Association of Neurological Surgeons Country of Publication: United States NLM ID: 0253357 Publication Model: Print Cited Medium: Print ISSN: 0022-3085 (Print) Linking ISSN: 00223085 NLM ISO Abbreviation: J Neurosurg Subsets: MEDLINE |
أسماء مطبوعة: | Publication: Charlottesville, VA : American Association of Neurological Surgeons Original Publication: Chicago [etc.] |
مواضيع طبية MeSH: | Nucleic Acid Hybridization*, Craniopharyngioma/*genetics , Pituitary Neoplasms/*genetics, Adolescent ; Adult ; Aged ; Child ; Chromosome Aberrations ; Craniopharyngioma/etiology ; Female ; Gene Dosage ; Genetic Predisposition to Disease/genetics ; Humans ; Male ; Middle Aged ; Oncogenes/genetics ; Pituitary Neoplasms/etiology |
مستخلص: | Object: Craniopharyngioma is the most common childhood brain tumor and is thought to arise from embryonic remnants of the Rathke pouch. Some craniopharyngiomas are monoclonal in origin and hence presumably harbor somatic genetic alterations, although the precise molecular mechanisms involved in craniopharyngioma development are unknown. The goal of this study was to identify genetic alterations in craniopharyngiomas. Methods: To gain insight into the molecular mechanisms involved in development of these tumors, the authors analyzed nine adamantinomatous craniopharyngiomas by using comparative genomic hybridization. Six tumors (67%) displayed at least one genomic alteration, and three had six or more alterations. Only two tumors displayed a decrease in DNA copy number, and in all others an increase in DNA copy number was noted. Conclusions: The authors conclude that a subset of craniopharyngiomas consists of monoclonal tumors arising from activation of oncogenes located at specific chromosomal loci. |
تواريخ الأحداث: | Date Created: 20030128 Date Completed: 20030212 Latest Revision: 20041117 |
رمز التحديث: | 20231215 |
DOI: | 10.3171/jns.2003.98.1.0162 |
PMID: | 12546365 |
قاعدة البيانات: | MEDLINE |
تدمد: | 0022-3085 |
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DOI: | 10.3171/jns.2003.98.1.0162 |