دورية أكاديمية
Disruption of gap junctions in toxicity and carcinogenicity.
| العنوان: | Disruption of gap junctions in toxicity and carcinogenicity. |
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| المؤلفون: | Chipman JK; School of Biosciences, The University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom. j.k.chipman@bham.ac.uk, Mally A, Edwards GO |
| المصدر: | Toxicological sciences : an official journal of the Society of Toxicology [Toxicol Sci] 2003 Feb; Vol. 71 (2), pp. 146-53. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: United States NLM ID: 9805461 Publication Model: Print Cited Medium: Print ISSN: 1096-6080 (Print) Linking ISSN: 10960929 NLM ISO Abbreviation: Toxicol Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 1999- : Cary, NC : Oxford University Press Original Publication: Orlando, FL : Academic Press, c1998- |
| مواضيع طبية MeSH: | Carcinogens/*toxicity , Gap Junctions/*drug effects, Animals ; Cells, Cultured ; Connexins/metabolism ; Down-Regulation ; Gap Junctions/pathology ; Humans |
| مستخلص: | Although the specific role of connexin-mediated gap junctional intercellular communication in the control of cell homeostasis, proliferation, and death are still not clear, several lines of evidence support these roles. The disturbance of this communication, through multiple mechanisms, may in the short term be a protective mechanism to limit the spread of toxicity in a tissue following chemical or radiation damage. However, sustained downregulation confers a loss of tumor-suppressive action. Consequently, connexin dysfunction has been associated with both the action of many carcinogens and being a feature of cancer per se. Connexins offer not only a target for cancer chemoprevention but also for exploitation in chemotherapy through the "bystander" effect. |
| Number of References: | 84 |
| المشرفين على المادة: | 0 (Carcinogens) 0 (Connexins) |
| تواريخ الأحداث: | Date Created: 20030204 Date Completed: 20030729 Latest Revision: 20190513 |
| رمز التحديث: | 20240627 |
| DOI: | 10.1093/toxsci/71.2.146 |
| PMID: | 12563100 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1096-6080 |
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| DOI: | 10.1093/toxsci/71.2.146 |