دورية أكاديمية
Tissue pharmacokinetics of florfenicol in pigs experimentally infected with Actinobacillus pleuropneumoniae.
| العنوان: | Tissue pharmacokinetics of florfenicol in pigs experimentally infected with Actinobacillus pleuropneumoniae. |
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| المؤلفون: | Li JZ; Division of Pharmacology and Clinical Pharmacology, College of Veterinary Medicine, South China Agricultural University, Guangzhou, PR China., Fung KF, Chen ZL, Zeng ZL, Zhang J |
| المصدر: | European journal of drug metabolism and pharmacokinetics [Eur J Drug Metab Pharmacokinet] 2002 Oct-Dec; Vol. 27 (4), pp. 265-71. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer France Country of Publication: France NLM ID: 7608491 Publication Model: Print Cited Medium: Print ISSN: 0378-7966 (Print) Linking ISSN: 03787966 NLM ISO Abbreviation: Eur J Drug Metab Pharmacokinet Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2010- >: Paris : Springer France Original Publication: Paris, Edifor. |
| مواضيع طبية MeSH: | Actinobacillus pleuropneumoniae*, Actinobacillus Infections/*metabolism , Anti-Bacterial Agents/*pharmacokinetics , Thiamphenicol/*analogs & derivatives , Thiamphenicol/*pharmacokinetics, Actinobacillus Infections/microbiology ; Animals ; Chloramphenicol/pharmacokinetics ; Chromatography, High Pressure Liquid ; Diet ; Injections, Intramuscular ; Reproducibility of Results ; Swine ; Tissue Distribution |
| مستخلص: | Unlabelled: The aim of this study has been to determine the tissue pharmacokinetic parameters of florfenicol in the pigs experimentally infected with Actinobacillus pleuropneumoniae. 21 crossed-bred (Duroc x Landrace x Yorkshire) local species of pigs were infected experimentally with Actinobacillus pleuropneumoniae serotype 1 and confirmed as typical sub-acute pleuropneumonia. A single dose of 20 mg/kg body weight of florfenicol, a novel animal-using antibiotic, was administrated intramuscularly in the pigs and then samples of blood, lung, trachea with bronchi, liver, kidney and muscle were taken at scheduled time points. Drug concentrations were determined by high performance liquid chromatography (HPLC) with an ultraviolet detector via extraction with ethyl acetate under nitrogen flow. The statistic moment theory (SMT) mathematic package was applied to calculate the tissue pharmacokinetic parameters of florfenicol in the infected model. AUC of lung, trachea with bronchi, liver, kidney and muscle were 121.69, 79.37, 81.05, 181.2, and 94.07 mg/l x h, respectively, MRT were from 34.66 to 90.17 h, and t1/2beta from 24.75 to 69.34 h, respectively. Conclusions: Florfenicol was widely distributed in these tissues and maintained the effective therapeutic concentrations especially in the respiratory tract tissues that are the target organs of Actinobacillus pneuropneumoniae. Clinical Significance: Tissue pharmacokinetic data could be evidence for regime designing of florfenicol in treatment of porcine pleuropneumonia. |
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| المشرفين على المادة: | 0 (Anti-Bacterial Agents) 66974FR9Q1 (Chloramphenicol) 9J97307Y1H (florfenicol) FLQ7571NPM (Thiamphenicol) |
| تواريخ الأحداث: | Date Created: 20030218 Date Completed: 20030721 Latest Revision: 20181113 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1007/BF03192337 |
| PMID: | 12587956 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 0378-7966 |
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| DOI: | 10.1007/BF03192337 |