التفاصيل البيبلوغرافية
| العنوان: |
Lamotrigine monotherapy improves health-related quality of life in epilepsy: a double-blind comparison with valproate. |
| المؤلفون: |
Chris Sackellares J; University of Florida, Gainesville, FL, USA, Jacqueline Kwong W, Vuong A, Hammer AE, Barrett PS |
| المصدر: |
Epilepsy & behavior : E&B [Epilepsy Behav] 2002 Aug; Vol. 3 (4), pp. 376-382. |
| نوع المنشور: |
Journal Article |
| اللغة: |
English |
| بيانات الدورية: |
Publisher: Academic Press Country of Publication: United States NLM ID: 100892858 Publication Model: Print Cited Medium: Internet ISSN: 1525-5069 (Electronic) Linking ISSN: 15255050 NLM ISO Abbreviation: Epilepsy Behav Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: |
Original Publication: San Diego, CA : Academic Press, c2000- |
| مستخلص: |
The effects of monotherapy with lamotrigine on health-related quality of life were compared with those of valproate monotherapy in a randomized, double-blind trial designed to evaluate treatment-emergent weight changes in patients with epilepsy. At the end of 8 months of treatment, significantly more patients using lamotrigine compared with valproate experienced quality-of-life improvements on the Health Perceptions (42% vs 15%), Energy/Fatigue (47% vs 28%), and Social Isolation (35% vs 16%) subscales of the Quality of Life in Epilepsy-89 (QOLIE-89) questionnaire (P<0.05). Compared with valproate-treated patients, lamotrigine-treated patients were four times more likely to experience improvement in Health Perceptions, 2.3 times more likely to experience improvement in Energy/Fatigue, and 2.8 times more likely to experience improvement in Social Isolation (P<0.05). These quality-of-life improvements are consistent with the improvements in mood measured with the Beck Depression Inventory, the Cornell Dysthymia Rating Scale, and the Profile of Mood States among patients receiving lamotrigine. These data show that lamotrigine monotherapy provides benefits over valproate monotherapy in improving several aspects of health-related quality of life in patients with epilepsy. The observation that quality-of-life improvements during lamotrigine monotherapy occurred concurrently with improvements in mood suggests that the quality-of-life and mood changes may be causally related. |
| تواريخ الأحداث: |
Date Created: 20030301 Latest Revision: 20191120 |
| رمز التحديث: |
20231215 |
| DOI: |
10.1016/s1525-5050(02)00046-x |
| PMID: |
12609336 |
| قاعدة البيانات: |
MEDLINE |
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