دورية أكاديمية
أعرض في EDS

Pyloric ceca are significant sites of newly synthesized 22:6n-3 in rainbow trout (Oncorhynchus mykiss).

التفاصيل البيبلوغرافية
العنوان: Pyloric ceca are significant sites of newly synthesized 22:6n-3 in rainbow trout (Oncorhynchus mykiss).
المؤلفون: Bell MV; Institute of Aquaculture, School of Natural Sciences, University of Stirling, Stirling FK9 4LA, Scotland, United Kingdom. m.v.bell@stir.ac.uk, Dick JR, Porter AE
المصدر: Lipids [Lipids] 2003 Jan; Vol. 38 (1), pp. 39-44.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Wiley Subscription Services, Inc Country of Publication: United States NLM ID: 0060450 Publication Model: Print Cited Medium: Print ISSN: 0024-4201 (Print) Linking ISSN: 00244201 NLM ISO Abbreviation: Lipids Subsets: MEDLINE
أسماء مطبوعة: Publication: 2018- : Hoboken, NJ : Wiley Subscription Services, Inc.
Original Publication: Chicago, American Oil Chemists' Society.
مواضيع طبية MeSH: 5,8,11,14-Eicosatetraynoic Acid/*analogs & derivatives , Cecum/*metabolism , Fatty Acids, Omega-3/*biosynthesis , Oncorhynchus mykiss/*metabolism, 5,8,11,14-Eicosatetraynoic Acid/metabolism ; Animals ; Fatty Acids, Omega-3/chemistry ; Fish Oils/biosynthesis ; Liver/metabolism ; Pylorus
مستخلص: In this pulse-chase study, rainbow trout fed a diet containing deuterated (D5) (17,17,18,18,18)-18:3n-3 ethyl ester accumulated D5-22:6n-3 in pyloric ceca to a greater extent than in liver 2 d post-dose. The ratio of newly synthesized D5-22:6n-3 in ceca to that in liver 2 d after feeding D5-18:3n-3 was 4.7 +/- 1.2 when expressed as per mg tissue and 5.2 +/- 2.4 when expressed as per mg protein. The amount of D5-22:6n-3 in ceca then declined whereas that in liver and blood increased, with the ratio of ceca to liver falling to 1.7 and 1.4, respectively, by day 5 and approaching unity by day 9. A crude cecal mucosa fraction contained 123 +/- 50 ng D5-22:6n-3/mg protein/mg D5-18:3n-3 eaten 2 d after feeding the tracer, compared with 35 +/- 21 ng D5-22:6n-3/mg protein/mg D5-18:3n-3 eaten in liver. Three days later the amount in cecal mucosa had fallen by one-third and that in liver had increased threefold. Most of the D5-18:3n-3 was catabolized very rapidly. The ratio of D5-18:3n-3 to 21:4n-6 (a relatively inert FA marker) in the diet was 4.0, but this fell to 0.30 in ceca and ca. 0.8 in liver, blood, and whole carcass one day after feeding. These results indicate that ceca are active in the synthesis of 22:6n-3 and the oxidation of 18:3n-3.
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المشرفين على المادة: 0 (Fatty Acids, Omega-3)
0 (Fish Oils)
1191-85-1 (5,8,11,14-Eicosatetraynoic Acid)
19960-58-8 (5,8,11,14-heneicosatetraynoic acid)
تواريخ الأحداث: Date Created: 20030403 Date Completed: 20031219 Latest Revision: 20190814
رمز التحديث: 20231215
DOI: 10.1007/s11745-003-1029-5
PMID: 12669818
قاعدة البيانات: MEDLINE
الوصف
تدمد:0024-4201
DOI:10.1007/s11745-003-1029-5