التفاصيل البيبلوغرافية
| العنوان: |
In vitro activity of eight oral cephalosporins against Borrelia burgdorferi. |
| المؤلفون: |
Hunfeld KP; Institute of Medical Microbiology, University Hospital of Frankfurt, Paul-Ehrlich-Street 40, D-60596 Frankfurt/Main, Germany. k.hunfeld@em.uni-frankfurt.de, Rödel R, Wichelhaus TA |
| المصدر: |
International journal of antimicrobial agents [Int J Antimicrob Agents] 2003 Apr; Vol. 21 (4), pp. 313-8. |
| نوع المنشور: |
Journal Article |
| اللغة: |
English |
| بيانات الدورية: |
Publisher: Elsevier Science Publishers Country of Publication: Netherlands NLM ID: 9111860 Publication Model: Print Cited Medium: Print ISSN: 0924-8579 (Print) Linking ISSN: 09248579 NLM ISO Abbreviation: Int J Antimicrob Agents Subsets: MEDLINE |
| أسماء مطبوعة: |
Original Publication: Amsterdam : Elsevier Science Publishers, c1991- |
| مواضيع طبية MeSH: |
Borrelia burgdorferi Group/*drug effects , Cephalosporins/*pharmacology, Administration, Oral ; Humans ; In Vitro Techniques ; Microbial Sensitivity Tests |
| مستخلص: |
Oral cephalosporins have not previously been extensively tested against larger numbers of Borrelia burgdorferi isolates derived from different clinical and geographical sources. This study investigated the in vitro activity of eight oral cephalosporins in addition to ceftriaxone and apramycin, against 17 isolates of the B. burgdorferi complex, including one B. valaisiana and one B. bissettii tick isolate. Minimal inhibitory concentrations and minimal borreliacidal concentrations providing 100% killing of the final inoculum were determined by a standardised methodology in Barbour-Stoenner-Kelly-medium after 72 h of incubation. The rank order of potency was ceftriaxone>cefuroxime-axetil>cefixime, cefdinir>cefpodoxime>cefaclor >ceftibuten, loracarbef>cefetamet-pivoxil, apramycin. Our study demonstrates the superior in vitro effectiveness of ceftriaxone with good to excellent activity with the oral agents cefuroxime-axetil, cefixime and cefdinir against B. burgdorferi under strictly standardised test conditions. |
| المشرفين على المادة: |
0 (Cephalosporins) |
| تواريخ الأحداث: |
Date Created: 20030404 Date Completed: 20031205 Latest Revision: 20220321 |
| رمز التحديث: |
20231215 |
| DOI: |
10.1016/s0924-8579(03)00005-0 |
| PMID: |
12672576 |
| قاعدة البيانات: |
MEDLINE |
Full Text Finder