دورية أكاديمية
Metaplastic breast carcinoma: pathology and clinical outcome.
العنوان: | Metaplastic breast carcinoma: pathology and clinical outcome. |
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المؤلفون: | Bellino R; Department of Gynaecology and Obstetrics, Sant'Anna Hospital, University of Turin, Italy., Arisio R, D'Addato F, Attini R, Durando A, Danese S, Bertone E, Grio R, Massobrio M |
المصدر: | Anticancer research [Anticancer Res] 2003 Jan-Feb; Vol. 23 (1B), pp. 669-73. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: International Institute of Anticancer Research Country of Publication: Greece NLM ID: 8102988 Publication Model: Print Cited Medium: Print ISSN: 0250-7005 (Print) Linking ISSN: 02507005 NLM ISO Abbreviation: Anticancer Res Subsets: MEDLINE |
أسماء مطبوعة: | Publication: Attiki, Greece : International Institute of Anticancer Research Original Publication: Athens, Greece : Potamitis Press |
مواضيع طبية MeSH: | Breast Neoplasms/*pathology, Adult ; Aged ; Aged, 80 and over ; Breast Neoplasms/drug therapy ; Breast Neoplasms/metabolism ; Breast Neoplasms/surgery ; Carcinoma/metabolism ; Carcinoma/pathology ; Carcinoma, Squamous Cell/metabolism ; Carcinoma, Squamous Cell/pathology ; Female ; Follow-Up Studies ; Humans ; Immunohistochemistry ; Metaplasia ; Middle Aged ; Neoadjuvant Therapy ; Neoplasm Staging ; Receptor, ErbB-2/biosynthesis ; Receptors, Estrogen/biosynthesis ; Receptors, Progesterone/biosynthesis ; Treatment Outcome ; Tumor Suppressor Protein p53/biosynthesis |
مستخلص: | Metaplastic breast carcinomas are rare neoplasms showing both carcinomatous and sarcomatous elements. In this report we describe eleven cases of metaplastic breast carcinoma focusing on pathological features and the clinical behaviour of six patients with breast carcinoma with chondroid metaplasia (MCC). We collected eleven cases from 1996 to 2001: immunohistochemical tests were performed in order to obtain data on estrogen and progesterone receptors and the production of p53 gene and HER/2 neu. Neoangiogenesis was studied counting vessels immunohistochemically-stained with CD31 antibody. Six cases showed chondroid metaplasia, three cases were spindle cell carcinoma and two were metaplastic squamous carcinoma. The majority of patients (64%) had pT2 tumors without axillary node metastases: only two cases with spindle or squamous metaplasia showed nodal involvement. Fifty percent of MCC were pT1b-c tumors: no axillary metastases were observed. Vascular invasion was observed in all squamous and spindle cell types and in 66% of MCC: estrogen and progesterone receptors were absent in 90% of the tumors. Immunohistochemical staining for HER2/neu was detected in 72% of spindle cell and squamous carcinomas and in 33% of MCC. Three cases staining highly for p53 were chondroid carcinomas: the staining was uniform both in carcinomatous and in sarcomatous tissue. The majority of metaplastic carcinomas had high angionesis. One patient with a chondroid metaplastic carcinoma was found to be a carrier of a BRCA1 mutation similar to the one responsible for sickle cell disease, possibly altering the spatial structure of the gene product. Only six patients had follow-up periods longer than 36 months: five women were alive and disease-free: one patient with pT2N1 squamous metaplastic carcinoma died of disease 14 months after diagnosis. The six women with MCC were alive and disease-free. Surgical and adjuvant treatment should follow the guidelines for the other most common breast cancers even if the need for chemotherapy is unknown due to the absence of large series randomized or observational data. |
المشرفين على المادة: | 0 (Receptors, Estrogen) 0 (Receptors, Progesterone) 0 (Tumor Suppressor Protein p53) EC 2.7.10.1 (Receptor, ErbB-2) |
تواريخ الأحداث: | Date Created: 20030412 Date Completed: 20030417 Latest Revision: 20141120 |
رمز التحديث: | 20240627 |
PMID: | 12680165 |
قاعدة البيانات: | MEDLINE |
تدمد: | 0250-7005 |
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