دورية أكاديمية
A new phytotoxic nonenolide from Phoma herbarum.
| العنوان: | A new phytotoxic nonenolide from Phoma herbarum. |
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| المؤلفون: | Rivero-Cruz JF; Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, México D.F. 04510, México., Macías M, Cerda-García-Rojas CM, Mata R |
| المصدر: | Journal of natural products [J Nat Prod] 2003 Apr; Vol. 66 (4), pp. 511-4. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Society of Pharmacognosy Country of Publication: United States NLM ID: 7906882 Publication Model: Print Cited Medium: Print ISSN: 0163-3864 (Print) Linking ISSN: 01633864 NLM ISO Abbreviation: J Nat Prod Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Cincinnati, American Society of Pharmacognosy. |
| مواضيع طبية MeSH: | 3',5'-Cyclic-AMP Phosphodiesterases/*antagonists & inhibitors , Calmodulin/*antagonists & inhibitors , Enzyme Inhibitors/*isolation & purification , Fungi/*chemistry , Lactones/*isolation & purification, Amaranthus/drug effects ; Animals ; Brain/drug effects ; Cattle ; Cyclic Nucleotide Phosphodiesterases, Type 1 ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/pharmacology ; Heterocyclic Compounds, 1-Ring ; Inhibitory Concentration 50 ; Lactones/chemistry ; Lactones/pharmacology ; Molecular Conformation ; Molecular Structure ; Nuclear Magnetic Resonance, Biomolecular ; Seeds/drug effects ; Zea mays |
| مستخلص: | Reinvestigation of the fermentation broth and mycelium of the fungus Phoma herbarum led to the isolation of a new phytotoxic nonenolide, namely, (7R,9R)-7-hydroxy-9-propyl-5-nonen-9-olide, which was designated with the trivial name herbarumin III (3). The known compounds herbarumins I (1) and II (2) were also obtained. The structure of 3 was elucidated by spectroscopic methods and molecular modeling. Compounds 1-3 interacted with bovine-brain calmodulin and inhibited the activation of the calmodulin-dependent enzyme cAMP phosphodiesterase. |
| المشرفين على المادة: | 0 (Calmodulin) 0 (Enzyme Inhibitors) 0 (Heterocyclic Compounds, 1-Ring) 0 (Lactones) 0 (herbarumin I) 0 (herbarumin II) 0 (herbarumin III) EC 3.1.4.17 (3',5'-Cyclic-AMP Phosphodiesterases) EC 3.1.4.17 (Cyclic Nucleotide Phosphodiesterases, Type 1) |
| تواريخ الأحداث: | Date Created: 20030426 Date Completed: 20031002 Latest Revision: 20071115 |
| رمز التحديث: | 20240627 |
| DOI: | 10.1021/np020501t |
| PMID: | 12713403 |
| قاعدة البيانات: | MEDLINE |
Find this issue from the American Chemical Society | تدمد: | 0163-3864 |
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| DOI: | 10.1021/np020501t |