دورية أكاديمية
Elicitation, a new window into plant chemodiversity and phytochemical drug discovery.
| العنوان: | Elicitation, a new window into plant chemodiversity and phytochemical drug discovery. |
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| المؤلفون: | Poulev A; Biotech Center, Foran Hall, 59 Dudley Road, Cook College, Rutgers University, New Brunswick, New Jersey 08901-8520, USA., O'Neal JM, Logendra S, Pouleva RB, Timeva V, Garvey AS, Gleba D, Jenkins IS, Halpern BT, Kneer R, Cragg GM, Raskin I |
| المصدر: | Journal of medicinal chemistry [J Med Chem] 2003 Jun 05; Vol. 46 (12), pp. 2542-7. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print Cited Medium: Print ISSN: 0022-2623 (Print) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Washington Dc : American Chemical Society Original Publication: [Easton, Pa.] : American Chemical Society, [c1963- |
| مواضيع طبية MeSH: | Hydroponics*, Plant Extracts/*pharmacology , Plant Roots/*chemistry , Plants, Medicinal/*chemistry, Anti-Bacterial Agents ; Anti-Infective Agents/chemistry ; Anti-Infective Agents/pharmacology ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Bacteria/drug effects ; Colony Count, Microbial ; Fungi/drug effects ; Plant Extracts/chemistry ; Plants, Medicinal/classification ; Tumor Cells, Cultured |
| مستخلص: | Plant extracts collected from the wild are important sources for drug discovery. However, these extracts suffer from a lack of reproducible bioactivity and chemical composition caused by the highly inducible, variable, and transitory nature of plant secondary metabolism. Here, we demonstrate that exposing roots of hydroponically grown plants to chemical elicitors selectively and reproducibly induced the production of bioactive compounds, dramatically increased the hit rate, and more than doubled the number of plant species showing in vitro activity against bacteria, fungi, or cancer. Elicitation performed under controlled conditions dramatically improves reliability and efficiency of plant extracts in drug discovery while preserving wild species and their habitats. |
| المشرفين على المادة: | 0 (Anti-Bacterial Agents) 0 (Anti-Infective Agents) 0 (Antineoplastic Agents) 0 (Plant Extracts) |
| تواريخ الأحداث: | Date Created: 20030530 Date Completed: 20030711 Latest Revision: 20061115 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1021/jm020359t |
| PMID: | 12773057 |
| قاعدة البيانات: | MEDLINE |
Find this issue from the American Chemical Society | تدمد: | 0022-2623 |
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| DOI: | 10.1021/jm020359t |