دورية أكاديمية
Dissecting adrenal and behavioral responses to stress by targeted gene inactivation in mice.
| العنوان: | Dissecting adrenal and behavioral responses to stress by targeted gene inactivation in mice. |
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| المؤلفون: | Brewer JA; Department of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA., Bethin KE, Schaefer ML, Muglia LM, Vogt SK, Weninger SC, Majzoub JA, Muglia LJ |
| المصدر: | Stress (Amsterdam, Netherlands) [Stress] 2003 Jun; Vol. 6 (2), pp. 121-5. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 9617529 Publication Model: Print Cited Medium: Print ISSN: 1025-3890 (Print) Linking ISSN: 10253890 NLM ISO Abbreviation: Stress Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Informa Healthcare Original Publication: [Amsterdam?] : Harwood Academic Publishers, |
| مواضيع طبية MeSH: | Adrenal Glands/*physiology , Behavior, Animal/*physiology , Corticotropin-Releasing Hormone/*genetics , Stress, Physiological/*physiopathology, Animals ; Disease Models, Animal ; Mice ; Mice, Knockout ; Stress, Physiological/genetics |
| مستخلص: | To define the molecular pathways modulating adrenal and behavioral responses to stress, we have generated mice with inactivation of hypothalamic neuropeptides and signaling pathways. Studies in mice deficient in corticotropin-releasing hormone (CRH) have revealed the essential role for CRH in adrenal glucocorticoid production in response to many physiological and psychological stressors. Immune system activation in CRH-deficient mice provides a unique exception to the necessity for CRH in stimulating adrenal glucocorticoid production. By analyzing mice deficient in interleukin-6 (IL-6) and CRH, we find that restoration of glucocorticoid output with inflammation is largely mediated by dysregulated IL-6 production. Current studies focus on identifying cellular and gene targets by which glucocorticoids regulate immune system function. In contrast to impaired adrenocortical responses to stress, CRH-deficient mice exhibit normal behavioral responses to stress. To determine signaling pathways that may contribute to the behavioral responses to stress, we have generated and analyzed mice deficient in adenylyl cyclase type 8 (AC8). AC8 deficient mice have intact adrenocortical responses to stress, but an inability to undergo stress-induced alterations in behavior. |
| Number of References: | 28 |
| المشرفين على المادة: | 9015-71-8 (Corticotropin-Releasing Hormone) |
| تواريخ الأحداث: | Date Created: 20030531 Date Completed: 20030806 Latest Revision: 20081121 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1080/1025389031000116460 |
| PMID: | 12775331 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1025-3890 |
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| DOI: | 10.1080/1025389031000116460 |