دورية أكاديمية
Management of high-risk gestational trophoblastic disease--the Memorial Hospital experience.
| العنوان: | Management of high-risk gestational trophoblastic disease--the Memorial Hospital experience. |
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| المؤلفون: | Jones WB; Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA., Cardinale C, Lewis JL Jr |
| المصدر: | International journal of gynecological cancer : official journal of the International Gynecological Cancer Society [Int J Gynecol Cancer] 1997 Jan; Vol. 7 (1), pp. 27-33. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: BMJ Country of Publication: England NLM ID: 9111626 Publication Model: Print Cited Medium: Print ISSN: 1048-891X (Print) Linking ISSN: 1048891X NLM ISO Abbreviation: Int J Gynecol Cancer Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Publication: 2019- : [London] : BMJ Original Publication: Cambridge, MA, USA : Blackwell Scientific Publications, c1991- |
| مستخلص: | Thirty-two patients with high-risk gestational trophoblastic disease (GTD), defined as metastases to the brain or liver (regardless of hCG level or duration of disease) or prior unsuccessful chemotherapy are reviewed. In this classification, an antecedent term pregnancy is not considered to be an independent high-risk factor. Initial chemotherapy in 15 (46.8%) patients consisted of methotrexate, actinomycin D, and chlorambucil (MAC), actinomycin D alone in seven (21.8%), etoposide, methotrexate, actinomycin D, cytoxan on covin (EMACO) EMACO in three (9.4%), ITMA (hydroxyurea, vincristine, methotrexate, folinic acid, cyclophosphamide, actinomycin D, adriamycin, and melphalan) in three (9.4%). The remaining patients were treated with actinomycin D and 6-mercaptopurine (1), CHAMOCA (1), carboplatin and Taxol (1), and methotrexate (1). All patients with brain metastases were treated with cranial radiotherapy. Overall complete remission was achieved in 14 of 32 (43.7%) patients. Five of 9 (55.5%) patients whose disease followed a term pregnancy survived compared to nine of 23 (39.1%) patients whose disease followed other types of pregnancies. The data analyzed according to the clinical classification of 'high-risk' indicates that an overall survival rate of 70% was achieved. The Memorial Hospital classification therefore identifies patients who need primary chemotherapy more aggressive than MAC and similar to the WHO scoring system is a better predictor of survival than the clinical classification. |
| تواريخ الأحداث: | Date Created: 19970101 Date Completed: 20031202 Latest Revision: 20191025 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1046/j.1525-1438.1997.00409.x |
| PMID: | 12795801 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1048-891X |
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| DOI: | 10.1046/j.1525-1438.1997.00409.x |