دورية أكاديمية
أعرض في EDS

Calcium dobesilate potentiates endothelium-derived hyperpolarizing factor-mediated relaxation of human penile resistance arteries.

التفاصيل البيبلوغرافية
العنوان: Calcium dobesilate potentiates endothelium-derived hyperpolarizing factor-mediated relaxation of human penile resistance arteries.
المؤلفون: Angulo J; Fundación para la Investigación y el Desarrollo en Andrología, Spain., Cuevas P, Fernández A, Gabancho S, Videla S, Sáenz de Tejada I
المصدر: British journal of pharmacology [Br J Pharmacol] 2003 Jun; Vol. 139 (4), pp. 854-62.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Wiley Country of Publication: England NLM ID: 7502536 Publication Model: Print Cited Medium: Print ISSN: 0007-1188 (Print) Linking ISSN: 00071188 NLM ISO Abbreviation: Br J Pharmacol Subsets: MEDLINE
أسماء مطبوعة: Publication: London : Wiley
Original Publication: London, Macmillian Journals Ltd.
مواضيع طبية MeSH: Biological Factors/*physiology , Calcium Dobesilate/*pharmacokinetics , Muscle Relaxation/*drug effects , Penile Erection/*drug effects , Penis/*blood supply , Penis/*drug effects, Animals ; Calcium Dobesilate/administration & dosage ; Drug Synergism ; Electric Stimulation ; Endothelium/drug effects ; Endothelium/physiopathology ; Humans ; Injections, Intravenous ; Male ; Muscle Relaxation/physiology ; Muscle, Smooth, Vascular/drug effects ; Nitric Oxide Synthase/physiology ; Penile Erection/physiology ; Penis/physiopathology ; Rats ; Rats, Sprague-Dawley ; Vascular Resistance/drug effects ; Vascular Resistance/physiology ; Vasodilation/drug effects ; Vasodilation/physiology
مستخلص: 1 We have evaluated the participation of endothelium-derived hyperpolarizing factor (EDHF) in the endothelium-dependent relaxation of isolated human penile resistance arteries (HPRA) and human corpus cavernosum (HCC) strips. In addition, the effect of the angioprotective agent, calcium dobesilate (DOBE), on the endothelium-dependent relaxation of these tissues was investigated. 2 Combined inhibition of nitric oxide synthase (NOS) and cyclooxygenase (COX) nearly abolished the endothelium-dependent relaxation to acetylcholine (ACh) in HCC, while 60% relaxation of HPRA was observed under these conditions. Endothelium-dependent relaxation of HPRA resistant to NOS and COX inhibition was prevented by raising the extracellular concentration of K(+) (35 mM) or by blocking Ca(2)(+)-activated K(+) channels, with apamin (APA; 100 nM) and charybdotoxin (CTX; 100 nM), suggesting the involvement of EDHF in these responses. 3 Endothelium-dependent relaxation to ACh was markedly enhanced by DOBE (10 micro M) in HPRA but not in HCC. The potentiating effects of DOBE on ACh-induced responses in HPRA, remained after NOS and COX inhibition, were reduced by inhibition of cytochrome P450 oxygenase with miconazole (0.3 mM) and were abolished by high K(+) or a combination of APA and CTX. 4 In vivo, DOBE (10 mg kg(-1) i.v.) significantly potentiated the erectile responses to cavernosal nerve stimulation in male rats. 5 EDHF plays an important role in the endothelium-dependent relaxation of HPRA but not in HCC. DOBE significantly improves endothelium-dependent relaxation of HPRA mediated by EDHF and potentiates erectile responses in vivo. Thus, EDHF becomes a new therapeutic target for the treatment of erectile dysfunction (ED) and DOBE could be considered a candidate for oral therapy for ED.
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المشرفين على المادة: 0 (Biological Factors)
0 (endothelium-dependent hyperpolarization factor)
5921X1560Q (Calcium Dobesilate)
EC 1.14.13.39 (Nitric Oxide Synthase)
تواريخ الأحداث: Date Created: 20030619 Date Completed: 20040324 Latest Revision: 20181113
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC1573889
DOI: 10.1038/sj.bjp.0705293
PMID: 12813009
قاعدة البيانات: MEDLINE
الوصف
تدمد:0007-1188
DOI:10.1038/sj.bjp.0705293