دورية أكاديمية
Novel alternative methods for the delivery of drugs for the treatment of asthma.
| العنوان: | Novel alternative methods for the delivery of drugs for the treatment of asthma. |
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| المؤلفون: | Chan HK; Faculty of Pharmacy, A15, University of Sydney, Sydney NSW 2006, Australia. kimc@pharm.usyd.edu.au, Chew NY |
| المصدر: | Advanced drug delivery reviews [Adv Drug Deliv Rev] 2003 Jul 18; Vol. 55 (7), pp. 793-805. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Publishers, B.V Country of Publication: Netherlands NLM ID: 8710523 Publication Model: Print Cited Medium: Print ISSN: 0169-409X (Print) Linking ISSN: 0169409X NLM ISO Abbreviation: Adv Drug Deliv Rev Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam : Elsevier Science Publishers, B.V., c1987- |
| مواضيع طبية MeSH: | Anti-Asthmatic Agents/*administration & dosage , Asthma/*drug therapy, Administration, Inhalation ; Aerosols ; Anti-Asthmatic Agents/therapeutic use ; Chemistry, Pharmaceutical ; Equipment and Supplies ; Humans ; Nebulizers and Vaporizers ; Powders ; Solvents ; Technology, Pharmaceutical |
| مستخلص: | Successful delivery of dry powder aerosols to the lung requires careful consideration of the powder production process, formulation and inhaler device. Newer production methods are emerging to prepare powders with desirable characteristics for inhalational administration. The conventional formulation approach of adding coarse lactose carriers to the drug to form binary powder systems to enhance powder flow and dispersion properties has been expanded to using finer carrier particles and hydrophobic materials, as well as ternary systems. Particle morphology and surface properties have also been explored to enhance powder performance. For the inhaler device, the new generation inhalers are designed to reduce or completely decouple the influence of air flow on the aerosol generation. Each of these determinants for powder aerosol delivery is reviewed with a strong focus on the patent literature that contains enormous information about the latest development in this field. |
| Number of References: | 70 |
| المشرفين على المادة: | 0 (Aerosols) 0 (Anti-Asthmatic Agents) 0 (Powders) 0 (Solvents) |
| تواريخ الأحداث: | Date Created: 20030705 Date Completed: 20040115 Latest Revision: 20191107 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/s0169-409x(03)00078-4 |
| PMID: | 12842601 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0169-409X |
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| DOI: | 10.1016/s0169-409x(03)00078-4 |