دورية أكاديمية
beta-Lactam antibiotic modulation of murine neutrophil cytokinesis.
| العنوان: | beta-Lactam antibiotic modulation of murine neutrophil cytokinesis. |
|---|---|
| المؤلفون: | Kenny MT; Marion Merrell Dow Research Institute, Indianapolis, Indiana 46268-0460., Balistreri FJ, Torney HL |
| المصدر: | Immunopharmacology and immunotoxicology [Immunopharmacol Immunotoxicol] 1992; Vol. 14 (4), pp. 797-811. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 8800150 Publication Model: Print Cited Medium: Print ISSN: 0892-3973 (Print) Linking ISSN: 08923973 NLM ISO Abbreviation: Immunopharmacol Immunotoxicol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Informa Healthcare Original Publication: New York, N.Y. : Marcel Dekker, c1987- |
| مواضيع طبية MeSH: | Anti-Bacterial Agents/*pharmacology , Cell Division/*drug effects , Neutrophils/*drug effects, Animals ; Cell Adhesion/drug effects ; Chlorpromazine/pharmacology ; Male ; Mice ; Mice, Inbred BALB C ; Neutrophils/cytology ; Neutrophils/physiology ; beta-Lactams |
| مستخلص: | Fourteen cephalosporins, 11 penicillins and 1 monobactam were evaluated for their in vitro modulation of murine neutrophil cytokinesis. As a result, the beta-lactam antibiotics were placed into 6 groups based on their effect on random (R) and FMLP-directed (D) migration [Group 1 (no effect): cephalosporin C; Group 2 (R-->D decreases): cloxacillin, cefotaxime, ceftazadime, cefuroxime, cephalothin, cephapirin, cephadine, nafcillin, piperacillin, ticarcillin, ampicillin, oxacillin, aztreonam; Group 3 (R increases D-->): cephaloridine; Group 4 (R increases D increases): cefsulodin; Group 5 (R increases D decreases): cefoperazone, cefoxitin, ceftriaxone, 6-amino-penicillanic acid; Group 6 (R decreases D decreases): cefadroxil, cefazolin, penicillin G, methicillin]. Trypan blue exclusion studies showed that inhibition of R and D by Group 6 beta-lactam antibiotics is not due to overt cytotoxicity. beta-lactam antibiotics inhibiting D also increased neutrophil adherence to plastic at a concentration of 1000 microM. Finally, the [Ca++] inhibitor chlorpromazine significantly abrogates beta-lactam- and FMLP-directed migration at a test concentration of 1 microM. |
| المشرفين على المادة: | 0 (Anti-Bacterial Agents) 0 (beta-Lactams) U42B7VYA4P (Chlorpromazine) |
| تواريخ الأحداث: | Date Created: 19920101 Date Completed: 19930415 Latest Revision: 20131121 |
| رمز التحديث: | 20231215 |
| DOI: | 10.3109/08923979209009236 |
| PMID: | 1294624 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 0892-3973 |
|---|---|
| DOI: | 10.3109/08923979209009236 |