دورية أكاديمية
Increased uncoupling of beta-, beta 1- and beta 2-adrenoceptor to myocardial contraction in failing human myocardium.
| العنوان: | Increased uncoupling of beta-, beta 1- and beta 2-adrenoceptor to myocardial contraction in failing human myocardium. |
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| المؤلفون: | Takahashi M; First Department of Internal Medicine, Shiga University of Medical Science, Japan., Shichiri G, Amano M, Kanamori T, Kinoshita M |
| المصدر: | Japanese circulation journal [Jpn Circ J] 1992 Jul; Vol. 56 (7), pp. 701-9. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Japanese Circulation Society Country of Publication: Japan NLM ID: 7806868 Publication Model: Print Cited Medium: Print ISSN: 0047-1828 (Print) Linking ISSN: 00471828 NLM ISO Abbreviation: Jpn Circ J Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Kyoto, Japanese Circulation Society. |
| مواضيع طبية MeSH: | Dobutamine/*pharmacology , Heart Failure/*metabolism , Isoproterenol/*pharmacology , Myocardial Contraction/*drug effects , Receptors, Adrenergic, beta/*metabolism , Terbutaline/*pharmacology, Adult ; Aged ; Binding, Competitive ; Down-Regulation ; Female ; Humans ; Iodocyanopindolol ; Male ; Middle Aged ; Pindolol/analogs & derivatives ; Pindolol/metabolism ; Quinazolines/metabolism |
| مستخلص: | Coupling of myocardial beta-, beta 1-, beta 2- and alpha-adrenoceptors (AR) to myocardial contraction was investigated in patients with various degrees of heart failure. With the use of delta Vcfc, a load independent parameter of myocardial contraction, AR mediated contraction was evaluated. beta-AR mediated contraction, delta Vcfc by infusion of a beta-AR agonist, isoproterenol, declined with the advancement of heart failure from 0.41 Circ/sec (NYHA I) to 0.31 (NYHA II), 0.22 (NYHA III) and 0.12 (NYHA IV). Dobutamine, a beta 1-AR full agonist, mediated delta Vcfc was 92-97% of that of isoproterenol. On the other hand, terbutaline sulfate, a full agonist to beta 2-AR, increased delta Vcfc partially in comparison with isoproterenol; 51% in NYHA I, 52% in NYHA II, 36% in NYHA III and 17% in NYHA IV. An alpha 1-AR agonist, methoxamine had little effect on myocardial contractility beta-AR and alpha-AR densities were analyzed by saturation binding isotherms of myocardial membrane fraction with 125I-Iodocyanopindolol (ICYP) and 3H-Bunazosin, respectively. beta-1 and beta 2-ARs were separated by competition binding of 125ICYP with a highly selective beta 1 AR antagonist, CGP20712A. There was a progressive down regulation of beta, beta 1- and beta 2-ARs with the advancement of heart failure. A new index was used to examine coupling of ARs to myocardial contraction; Coupling Index. The index was slightly decreased in NYHA II in beta- and beta 1-ARs. In beta 2-AR, the coupling index declined as heart failure advanced from NYHA I to NYHA IV.(ABSTRACT TRUNCATED AT 250 WORDS) |
| المشرفين على المادة: | 0 (Quinazolines) 0 (Receptors, Adrenergic, beta) 3S12J47372 (Dobutamine) 83498-72-0 (Iodocyanopindolol) 9UUW4V7G2H (bunazosin) BJ4HF6IU1D (Pindolol) L628TT009W (Isoproterenol) N8ONU3L3PG (Terbutaline) |
| تواريخ الأحداث: | Date Created: 19920701 Date Completed: 19920910 Latest Revision: 20190817 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1253/jcj.56.701 |
| PMID: | 1323000 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0047-1828 |
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| DOI: | 10.1253/jcj.56.701 |