التفاصيل البيبلوغرافية
| العنوان: |
[The pathogenesis of chronic Chagas' myocarditis: the role of autoimmune and microvascular factors]. |
| عنوان ترانسليتريتد: |
Patogênese da miocardite chagásica crônica: o papel de fatores autoimunes e microvasculares. |
| المؤلفون: |
Rossi MA; Departamento de Patologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Brasil., Mengel JO |
| المصدر: |
Revista do Instituto de Medicina Tropical de Sao Paulo [Rev Inst Med Trop Sao Paulo] 1992 Nov-Dec; Vol. 34 (6), pp. 593-9. |
| نوع المنشور: |
English Abstract; Journal Article; Research Support, Non-U.S. Gov't; Review |
| اللغة: |
Portuguese |
| بيانات الدورية: |
Publisher: Universidade de São Paulo, Instituto de Medicina Tropical de São Paulo Country of Publication: Brazil NLM ID: 7507484 Publication Model: Print Cited Medium: Print ISSN: 0036-4665 (Print) Linking ISSN: 00364665 NLM ISO Abbreviation: Rev Inst Med Trop Sao Paulo Subsets: MEDLINE |
| أسماء مطبوعة: |
Original Publication: Sao Paulo : Universidade de São Paulo, Instituto de Medicina Tropical de São Paulo |
| مواضيع طبية MeSH: |
Autoimmune Diseases/*etiology , Chagas Cardiomyopathy/*etiology, Autoimmune Diseases/immunology ; Autoimmune Diseases/physiopathology ; Chagas Cardiomyopathy/immunology ; Chagas Cardiomyopathy/physiopathology ; Chronic Disease ; Humans ; Microcirculation/physiopathology ; Myocarditis/etiology ; Myocarditis/immunology ; Myocarditis/physiopathology ; Myocardium/immunology |
| مستخلص: |
The pathogenesis of chronic chagasic myocarditis remains incompletely understood. Several hypotheses have been proposed: (1) direct tissue destruction by Trypanosoma cruzi; (2) neurogenic theory; (3) anti-heart immune reactions; and (4) microvascular disease. We present herein a dynamic alternative hypothesis. We believe that the development of myocarditis is related to progressive and additive focal cellular necrosis, and associated reactive and reparative myocardial fibrosis and surrounding myocytes hypertrophy. These processes may be initiated and perpetuated by autoimmune factors and alterations in the myocardial microcirculation. This could imply future therapeutic strategies in the management of chronic chagasic patients to optimize the medical treatment and hopefully improve the prognosis. |
| Number of References: |
54 |
| تواريخ الأحداث: |
Date Created: 19921101 Date Completed: 19940203 Latest Revision: 20190606 |
| رمز التحديث: |
20221213 |
| DOI: |
10.1590/s0036-46651992000600015 |
| PMID: |
1342130 |
| قاعدة البيانات: |
MEDLINE |
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