دورية أكاديمية
[Radiation protective properties of a synthetic antagonist of glucocorticoids RU 38486].
| العنوان: | [Radiation protective properties of a synthetic antagonist of glucocorticoids RU 38486]. |
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| عنوان ترانسليتريتد: | Issledovanie radiozashchitnogo deĭstviia sinteticheskogo antagonista gliukokortikoĭdov RU 38 486. |
| المؤلفون: | Seĭliev AA, Zvonareva NB, Zhivotovskiĭ BD, Khanson KP |
| المصدر: | Biulleten' eksperimental'noi biologii i meditsiny [Biull Eksp Biol Med] 1992 Jul; Vol. 114 (7), pp. 70-3. |
| نوع المنشور: | Comparative Study; English Abstract; Journal Article |
| اللغة: | Russian |
| بيانات الدورية: | Publisher: Administrativnoia Zdaniia Minzdrava Sssr Country of Publication: Russia (Federation) NLM ID: 0370627 Publication Model: Print Cited Medium: Print ISSN: 0365-9615 (Print) Linking ISSN: 03659615 NLM ISO Abbreviation: Biull Eksp Biol Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Moskva : Administrativnoia Zdaniia Minzdrava Sssr Original Publication: Moskva, Medgiz. |
| مواضيع طبية MeSH: | Radiation-Protective Agents*, Glucocorticoids/*antagonists & inhibitors , Mifepristone/*pharmacology, Animals ; Cell Death ; Chromatin/drug effects ; Chromatin/radiation effects ; In Vitro Techniques ; Male ; Mice ; Radiation Dosage ; Rats ; Receptors, Glucocorticoid/physiology ; T-Lymphocytes/drug effects ; T-Lymphocytes/radiation effects |
| مستخلص: | Radioprotective properties of synthetic antiglucocorticoid RU 38,486 were investigated. It was demonstrated that this antagonist of glucocorticoids possesses radioprotective effect in vitro and in vivo systems. Radioprotective properties at molecular level exhibited in inhibition of postirradiation endonuclease activation and in prevention of internucleosome chromatin degradation. Involvement of cytosol glucocorticoid receptors in initiation of radiation-induced programmed cell death is discussed. |
| المشرفين على المادة: | 0 (Chromatin) 0 (Glucocorticoids) 0 (Radiation-Protective Agents) 0 (Receptors, Glucocorticoid) 320T6RNW1F (Mifepristone) |
| تواريخ الأحداث: | Date Created: 19920701 Date Completed: 19921201 Latest Revision: 20141120 |
| رمز التحديث: | 20221208 |
| PMID: | 1421316 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0365-9615 |
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