دورية أكاديمية
Regionally specific modulation of brain apolipoprotein E in the mouse during the estrous cycle and by exogenous 17beta estradiol.
| العنوان: | Regionally specific modulation of brain apolipoprotein E in the mouse during the estrous cycle and by exogenous 17beta estradiol. |
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| المؤلفون: | Struble RG; Department of Neurology, Center for Alzheimer Disease and Related Disorders, PO Box 19628, Southern Illinois University School of Medicine, Springfield, IL 62794, USA. Rstrumble@siumed.edu, Rosario ER, Kircher ML, Ludwig SM, McAdamis PJ, Watabe K, McAsey ME, Cady C, Nathan BP |
| المصدر: | Experimental neurology [Exp Neurol] 2003 Oct; Vol. 183 (2), pp. 638-44. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Academic Press Country of Publication: United States NLM ID: 0370712 Publication Model: Print Cited Medium: Print ISSN: 0014-4886 (Print) Linking ISSN: 00144886 NLM ISO Abbreviation: Exp Neurol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Orlando Fl : Academic Press Original Publication: New York. |
| مواضيع طبية MeSH: | Apolipoproteins E/*metabolism , Brain/*drug effects , Brain/*metabolism , Estradiol/*pharmacology , Estrus/*metabolism, Animals ; Cerebellum/drug effects ; Cerebellum/metabolism ; Corpus Striatum/drug effects ; Corpus Striatum/metabolism ; Estrogen Receptor alpha ; Estrogen Receptor beta ; Female ; Frontal Lobe/drug effects ; Frontal Lobe/metabolism ; Gyrus Cinguli/drug effects ; Gyrus Cinguli/metabolism ; Hippocampus/drug effects ; Hippocampus/metabolism ; Immunohistochemistry ; Mice ; Mice, Inbred C57BL ; Olfactory Bulb/drug effects ; Olfactory Bulb/metabolism ; Receptors, Estrogen/metabolism |
| مستخلص: | Studies have suggested that 17beta estradiol (E2) can modify apolipoprotein E (apoE) expression. The current study determined if apoE protein varied in different regions of the mouse brain as a function of the estrous cycle and if E2 could increase apoE protein expression. In this study apoE concentration was lowest on estrus in the hippocampus, cingulate cortex and frontal cortex. In contrast, apoE concentration was highest on estrus in the olfactory bulb and cerebellum. There were no differences in the striatal apoE expression throughout the estrous cycle. Exogenous E2 significantly raised tissue levels of apoE in the olfactory bulb and cerebellum at 5 days after treatment. There was a slight, but nonsignificant increase in cortical expression of apoE and no change in striatum. Immunocytochemical localization studies found estrogen receptor alpha (ERalpha) and estrogen receptor beta (ERbeta) in cortical neurons and glia. In the cerebellum and olfactory bulb, ERbeta was seen primarily in glia. ERalpha was not observed in the cerebellum and was rare in the olfactory bulb. Neither ERalpha nor ERbeta was seen in the striatum. Our data show regional differences in the production of apoE throughout the estrous cycle. In addition, exogenous E2 has regionally specific effects on apoE expression. Regional variability in apoE production appears to vary as a function of the estrogen receptor subtype. |
| المشرفين على المادة: | 0 (Apolipoproteins E) 0 (Estrogen Receptor alpha) 0 (Estrogen Receptor beta) 0 (Receptors, Estrogen) 4TI98Z838E (Estradiol) |
| تواريخ الأحداث: | Date Created: 20031014 Date Completed: 20031031 Latest Revision: 20190722 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/s0014-4886(03)00215-2 |
| PMID: | 14552905 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0014-4886 |
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| DOI: | 10.1016/s0014-4886(03)00215-2 |