دورية أكاديمية
Functional repair of the corticospinal tract by delayed transplantation of olfactory ensheathing cells in adult rats.
| العنوان: | Functional repair of the corticospinal tract by delayed transplantation of olfactory ensheathing cells in adult rats. |
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| المؤلفون: | Keyvan-Fouladi N; Division of Neurobiology, Norman and Sadie Lee Research Centre, Medical Research Council, National Institute for Medical Research, London, NW7 1AA, United Kingdom., Raisman G, Li Y |
| المصدر: | The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2003 Oct 15; Vol. 23 (28), pp. 9428-34. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Society for Neuroscience Country of Publication: United States NLM ID: 8102140 Publication Model: Print Cited Medium: Internet ISSN: 1529-2401 (Electronic) Linking ISSN: 02706474 NLM ISO Abbreviation: J Neurosci Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Washington, DC : Society for Neuroscience Original Publication: [Baltimore, Md.] : The Society, c1981- |
| مواضيع طبية MeSH: | Olfactory Bulb/*transplantation , Pyramidal Tracts/*physiopathology , Spinal Cord Injuries/*physiopathology , Spinal Cord Injuries/*therapy, Animals ; Behavior, Animal ; Brain Tissue Transplantation ; Cell Movement ; Cells, Cultured ; Disease Models, Animal ; Disease Progression ; Female ; Fibroblasts/cytology ; Fibroblasts/metabolism ; Fibroblasts/transplantation ; Fibronectins/biosynthesis ; Graft Survival ; Motor Skills ; Motor Skills Disorders/etiology ; Motor Skills Disorders/therapy ; Olfactory Bulb/cytology ; Pyramidal Tracts/pathology ; Pyramidal Tracts/physiology ; Rats ; Rats, Inbred Strains ; Recovery of Function ; Schwann Cells/cytology ; Schwann Cells/transplantation ; Spinal Cord Injuries/complications ; Spinal Cord Injuries/pathology ; Time Factors ; Treatment Outcome |
| مستخلص: | Adult rats were trained to use their forepaws to retrieve a piece of food. Destruction of the dorsal corticospinal tract on one side at the level of the first cervical segment abolished the use of the ipsilateral forepaw for retrieval for at least 6 months after operation. Where a variable amount of the corticospinal tract was spared, there was a proportionate persistence of retrieval. In lesioned rats that had shown no retrieval for 8 weeks after operation, a suspension of olfactory ensheathing cells was injected into the lesion site. Starting between 1 and 3 weeks after transplantation, all rats with transplants bridging the lesion site resumed retrieval by the ipsilateral forepaw. Biotin dextran anterograde tracing shows regenerating corticospinal axons crossing the bridge, traveling caudally for approximately 10 mm in the distal part of the corticospinal tract and forming terminal arborizations in the spinal gray matter. Functional recovery can occur when only approximately 1% of the corticospinal tract axons are present. |
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| المشرفين على المادة: | 0 (Fibronectins) |
| تواريخ الأحداث: | Date Created: 20031017 Date Completed: 20031117 Latest Revision: 20220408 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC6740581 |
| PMID: | 14561871 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1529-2401 |
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