دورية أكاديمية
A diet promoting sugar dependency causes behavioral cross-sensitization to a low dose of amphetamine.
| العنوان: | A diet promoting sugar dependency causes behavioral cross-sensitization to a low dose of amphetamine. |
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| المؤلفون: | Avena NM; Princeton University, Department of Psychology, Green Hall, Washington Road, Princeton, NJ 08544, USA., Hoebel BG |
| المصدر: | Neuroscience [Neuroscience] 2003; Vol. 122 (1), pp. 17-20. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: United States NLM ID: 7605074 Publication Model: Print Cited Medium: Print ISSN: 0306-4522 (Print) Linking ISSN: 03064522 NLM ISO Abbreviation: Neuroscience Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: [New York?] : Elsevier Science Original Publication: Oxford, Elmsford, N. Y., Pergamon Press |
| مواضيع طبية MeSH: | Amphetamine/*pharmacology , Central Nervous System Stimulants/*pharmacology , Dopamine Agents/*pharmacology , Hyperkinesis/*chemically induced , Substance-Related Disorders/*etiology , Sucrose/*administration & dosage , Sucrose/*adverse effects, Amphetamine-Related Disorders/etiology ; Animals ; Behavior, Animal/drug effects ; Female ; Locomotion/drug effects ; Rats ; Rats, Sprague-Dawley |
| مستخلص: | Previous research in this laboratory has shown that a diet of intermittent excessive sugar consumption produces a state with neurochemical and behavioral similarities to drug dependency. The present study examined whether female rats on various regimens of sugar access would show behavioral cross-sensitization to a low dose of amphetamine. After a 30-min baseline measure of locomotor activity (day 0), animals were maintained on a cyclic diet of 12-h deprivation followed by 12-h access to 10% sucrose solution and chow pellets (12 h access starting 4 h after onset of the dark period) for 21 days. Locomotor activity was measured again for 30 min at the beginning of days 1 and 21 of sugar access. Beginning on day 22, all rats were maintained on ad libitum chow. Nine days later locomotor activity was measured in response to a single low dose of amphetamine (0.5 mg/kg). The animals that had experienced cyclic sucrose and chow were hyperactive in response to amphetamine compared with four control groups (ad libitum 10% sucrose and chow followed by amphetamine injection, cyclic chow followed by amphetamine injection, ad libitum chow with amphetamine, or cyclic 10% sucrose and chow with a saline injection). These results suggest that a diet comprised of alternating deprivation and access to a sugar solution and chow produces bingeing on sugar that leads to a long lasting state of increased sensitivity to amphetamine, possibly due to a lasting alteration in the dopamine system. |
| معلومات مُعتمدة: | MH-65024 United States MH NIMH NIH HHS |
| المشرفين على المادة: | 0 (Central Nervous System Stimulants) 0 (Dopamine Agents) 57-50-1 (Sucrose) CK833KGX7E (Amphetamine) |
| تواريخ الأحداث: | Date Created: 20031105 Date Completed: 20040319 Latest Revision: 20220311 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/s0306-4522(03)00502-5 |
| PMID: | 14596845 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0306-4522 |
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| DOI: | 10.1016/s0306-4522(03)00502-5 |