دورية أكاديمية
Protease and reverse transcriptase mutation patterns in HIV type 1 isolates from heavily treated persons: comparison of isolates from Northern California with isolates from other regions.
| العنوان: | Protease and reverse transcriptase mutation patterns in HIV type 1 isolates from heavily treated persons: comparison of isolates from Northern California with isolates from other regions. |
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| المؤلفون: | Gonzales MJ; Division of Infestious Diseases, Department of Medicine, Stanford University Medical Center, Stanford, CA 94305, USA., Belitskaya I, Dupnik KM, Rhee SY, Shafer RW |
| المصدر: | AIDS research and human retroviruses [AIDS Res Hum Retroviruses] 2003 Oct; Vol. 19 (10), pp. 909-15. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Mary Ann Liebert Country of Publication: United States NLM ID: 8709376 Publication Model: Print Cited Medium: Print ISSN: 0889-2229 (Print) Linking ISSN: 08892229 NLM ISO Abbreviation: AIDS Res Hum Retroviruses Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Larchmont, NY : Mary Ann Liebert Original Publication: [New York] : Mary Ann Liebert, [c1987- |
| مواضيع طبية MeSH: | HIV Protease/*genetics , HIV Reverse Transcriptase/*genetics , HIV-1/*genetics, California ; Genome, Viral ; HIV-1/isolation & purification ; Humans ; Molecular Sequence Data ; Mutation |
| مستخلص: | We compared HIV-1 subtype B reverse transcriptase (RT) and protease mutation patterns in isolates from heavily treated persons in Northern California with those from persons described in the published literature predominantly from other parts of the United States and Europe. There were few differences in the prevalence of single, double, and triple mutations between the two sets of sequences. More complex patterns of mutations could be characterized by clustering the sequences into eight groups of RT sequences and nine groups of protease sequences according to the presence of known drug-resistance mutations. This clustering accounted for 63% of the variation at RT inhibitor-resistance positions and 68% of the variation at protease inhibitor-resistance positions. The majority of clusters contained Northern California and literature sequences in similar proportions. |
| References: | AIDS. 2000 Jun 16;14(9):1203-10. (PMID: 10894285) J Infect Dis. 2001 Oct 15;184(8):998-1006. (PMID: 11574914) Nucleic Acids Res. 1999 Jan 1;27(1):348-52. (PMID: 9847225) Nature. 1995 Apr 6;374(6522):569-71. (PMID: 7700387) Ann Intern Med. 1998 Jun 1;128(11):906-11. (PMID: 9634429) Science. 2002 May 24;296(5572):1439-43. (PMID: 12029127) |
| معلومات مُعتمدة: | P01 GM066524-06 United States GM NIGMS NIH HHS; R25 TW009337 United States TW FIC NIH HHS; R01 AI046148 United States AI NIAID NIH HHS; P01 GM066524 United States GM NIGMS NIH HHS; R01 AI046148-08 United States AI NIAID NIH HHS |
| سلسلة جزيئية: | GENBANK AY305901; AY305902; AY305903; AY305904; AY305905; AY305906; AY305907; AY305908; AY305909; AY305910; AY305911; AY305912; AY305913; AY305914; AY305915; AY305916; AY305917; AY305918; AY305919; AY305920; AY305921; AY305922; AY305923; AY305924; AY305925; AY305926; AY305927; AY305928; AY305929; AY305930; AY305931; AY305932; AY305933; AY305934; AY305935; AY305936; AY305937; AY305938; AY305939; AY305940; AY305941; AY305942; AY305943; AY305944; AY305945; AY305946; AY305947; AY305948; AY305949; AY305950; AY305951; AY305952; AY305953; AY305954; AY305955; AY305956; AY305957; AY305958; AY305959; AY305960; AY305961; AY305962; AY305963; AY305964; AY305965; AY305966; AY305967; AY305968; AY305969; AY305970; AY305971; AY305972; AY305973; AY305974; AY305975; AY305976; AY305977; AY305978; AY305979; AY305980; AY305981; AY305982; AY305983; AY305984; AY305985; AY305986; AY305987; AY305988; AY305989; AY305990; AY305991; AY305992; AY305993; AY305994; AY305995; AY305996; AY305997; AY305998; AY305999; AY306000 |
| المشرفين على المادة: | EC 2.7.7.49 (HIV Reverse Transcriptase) EC 3.4.23.- (HIV Protease) |
| تواريخ الأحداث: | Date Created: 20031107 Date Completed: 20040217 Latest Revision: 20181113 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC2547469 |
| DOI: | 10.1089/088922203322493085 |
| PMID: | 14601580 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0889-2229 |
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| DOI: | 10.1089/088922203322493085 |