دورية أكاديمية
أعرض في EDS

Predisposition locus for major depression at chromosome 12q22-12q23.2.

التفاصيل البيبلوغرافية
العنوان: Predisposition locus for major depression at chromosome 12q22-12q23.2.
المؤلفون: Abkevich V; Myriad Genetics, Salt Lake City, UT, 84108, USA. victor@myriad.com, Camp NJ, Hensel CH, Neff CD, Russell DL, Hughes DC, Plenk AM, Lowry MR, Richards RL, Carter C, Frech GC, Stone S, Rowe K, Chau CA, Cortado K, Hunt A, Luce K, O'Neil G, Poarch J, Potter J, Poulsen GH, Saxton H, Bernat-Sestak M, Thompson V, Gutin A, Skolnick MH, Shattuck D, Cannon-Albright L
المصدر: American journal of human genetics [Am J Hum Genet] 2003 Dec; Vol. 73 (6), pp. 1271-81. Date of Electronic Publication: 2003 Nov 05.
نوع المنشور: Comparative Study; Journal Article
اللغة: English
بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 0370475 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0002-9297 (Print) Linking ISSN: 00029297 NLM ISO Abbreviation: Am J Hum Genet Subsets: MEDLINE
أسماء مطبوعة: Publication: 2008- : [Cambridge, MA] : Cell Press
Original Publication: Baltimore, American Society of Human Genetics.
مواضيع طبية MeSH: Chromosomes, Human, Pair 12/*genetics , Depressive Disorder, Major/*genetics , Genetic Linkage/*genetics, Chromosome Mapping ; Genetic Testing ; Genome, Human ; Humans ; Microsatellite Repeats/genetics ; Pedigree ; Utah
مستخلص: Major depression disorder is a common psychiatric disease with a major economic impact on society. In many cases, no effective treatment is available. The etiology of major depression is complex, but it is clear that the disease is, to a large extent, determined genetically, especially among individuals with a familial history of major depression, presumably through the involvement of multiple predisposition genes in addition to an environmental component. As a first step toward identification of chromosomal loci contributing to genetic predisposition to major depression, we have conducted a genomewide scan by using 628 microsatellite markers on 1,890 individuals from 110 Utah pedigrees with a strong family history of major depression. We identified significant linkage to major depression in males at marker D12S1300 (multipoint heterogeneity LOD score 4.6; P=.00003 after adjustment for multiple testing). With additional markers, the linkage evidence became highly significant, with the multipoint heterogeneity LOD score at marker D12S1706 increasing to 6.1 (P=.0000007 after adjustment for multiple testing). This study confirms the presence of one or more genes involved in psychiatric diseases on the q arm of chromosome 12 and provides strong evidence for the existence of a sex-specific predisposition gene to major depression at 12q22-q23.2.
References: Am J Hum Genet. 1997 Dec;61(6):1370-8. (PMID: 9399885)
Am J Hum Genet. 2003 Apr;72(4):879-90. (PMID: 12612864)
Mol Psychiatry. 2002;7(7):734-44. (PMID: 12192618)
Am J Hum Genet. 2001 Aug;69(2):428-33. (PMID: 11443544)
Mol Psychiatry. 2001 Jul;6(4):450-5. (PMID: 11443532)
Science. 1996 Nov 1;274(5288):740-3. (PMID: 8966556)
Am J Med Genet. 2002 Dec 8;114(8):980-7. (PMID: 12457397)
Proc Natl Acad Sci U S A. 1987 Apr;84(8):2363-7. (PMID: 3470801)
J Psychiatr Res. 1989;23(2):109-23. (PMID: 2585343)
J Clin Psychiatry. 1999;60 Suppl 2:57-62; discussion 75-6, 113-6. (PMID: 10073389)
Mol Psychiatry. 2002;7(4):424-7. (PMID: 11986988)
Biol Psychiatry. 2002 Nov 1;52(9):847-54. (PMID: 12399137)
Br J Psychiatry. 1994 Mar;164(3):355-8. (PMID: 8199789)
Am J Med Genet. 1999 Oct 15;88(5):567-87. (PMID: 10490718)
Behav Genet. 1991 May;21(3):211-42. (PMID: 1863257)
Biol Psychiatry. 1976 Dec;11(6):767-71. (PMID: 63295)
J Psychiatr Res. 1989;23(2):99-107. (PMID: 2585349)
Am J Med Genet. 1999 Jun 18;88(3):255-9. (PMID: 10374740)
Clin Genet. 2001 Feb;59(2):88-98. (PMID: 11260209)
Am J Hum Genet. 2002 Jun;70(6):1459-68. (PMID: 11957135)
Am J Hum Genet. 1984 Jul;36(4):836-57. (PMID: 6591796)
J Affect Disord. 1990 Apr;18(4):247-52. (PMID: 2140376)
J Affect Disord. 2003 Jan;73(1-2):183-97. (PMID: 12507751)
Psychol Med. 2001 May;31(4):605-16. (PMID: 11352363)
Arch Gen Psychiatry. 1986 Mar;43(3):222-6. (PMID: 3954541)
J Clin Psychiatry. 2001;62 Suppl 6:5-9. (PMID: 11310818)
Arch Gen Psychiatry. 1994 Jan;51(1):8-19. (PMID: 8279933)
Am J Hum Genet. 1998 Jul;63(1):259-66. (PMID: 9634505)
Acta Psychiatr Scand. 2000 Jul;102(1):44-51. (PMID: 10892609)
Science. 2000 Apr 28;288(5466):678-82. (PMID: 10784452)
Mol Psychiatry. 1998 Mar;3(2):162-8. (PMID: 9577841)
JAMA. 1997 Jan 22-29;277(4):333-40. (PMID: 9002497)
Br J Psychiatry. 1977 Apr;130:330-51. (PMID: 558030)
Am J Med Genet. 2001 Dec 8;105(8):690-9. (PMID: 11803516)
J Clin Psychiatry. 1999;60 Suppl 7:4-9; discussion 10-1. (PMID: 10326869)
Am J Hum Genet. 2000 Mar;66(3):1095-106. (PMID: 10712220)
Am J Med Genet. 2002 May 8;114(4):413-22. (PMID: 11992563)
Am J Hum Genet. 2001 Dec;69(6):1278-89. (PMID: 11668428)
Nat Genet. 1995 Nov;11(3):241-7. (PMID: 7581446)
Nat Genet. 2002 Jul;31(3):241-7. (PMID: 12053178)
Am J Psychiatry. 2000 Oct;157(10):1552-62. (PMID: 11007705)
Biotechniques. 1996 Jun;20(6):1004-6, 1008-10. (PMID: 8780871)
Acta Psychiatr Scand Suppl. 1994;376:7-15. (PMID: 8178688)
Am J Hum Genet. 2000 Jun;66(6):1845-56. (PMID: 10775531)
J Clin Psychiatry. 1993 Nov;54(11):405-18. (PMID: 8270583)
تواريخ الأحداث: Date Created: 20031108 Date Completed: 20040206 Latest Revision: 20220330
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC1180393
DOI: 10.1086/379978
PMID: 14606042
قاعدة البيانات: MEDLINE
الوصف
تدمد:0002-9297
DOI:10.1086/379978