دورية أكاديمية
Abnormal heart rate characteristics are associated with neonatal mortality.
| العنوان: | Abnormal heart rate characteristics are associated with neonatal mortality. |
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| المؤلفون: | Griffin MP; Department of Pediatrics, University of Virginia Health System, Charlottesville, Virginia 22908, USA. mpg7u@virginia.edu, O'Shea TM, Bissonette EA, Harrell FE Jr, Lake DE, Moorman JR |
| المصدر: | Pediatric research [Pediatr Res] 2004 May; Vol. 55 (5), pp. 782-8. Date of Electronic Publication: 2004 Jan 22. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 0100714 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0031-3998 (Print) Linking ISSN: 00313998 NLM ISO Abbreviation: Pediatr Res Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2012- : New York : Nature Publishing Group Original Publication: Basel ; New York : Karger. |
| مواضيع طبية MeSH: | Heart Rate* , Infant Mortality*, Birth Weight ; Gestational Age ; Glycosylation ; Hemoglobins/biosynthesis ; Hospital Mortality ; Humans ; Infant, Newborn ; Infant, Newborn, Diseases ; Intensive Care Units, Neonatal ; Intensive Care, Neonatal ; Logistic Models ; ROC Curve ; Regression Analysis ; Sepsis ; Severity of Illness Index ; Time Factors |
| مستخلص: | Estimating the risk of in-hospital mortality in the newborn intensive care unit can provide important information for health-care providers, and illness severity scores have been devised to provide mortality risk estimates. Calculation of illness severity scores is time-consuming, and the information used to predict mortality is collected only for the first 12 to 24 h of life. A noninvasive continuous measure that uses information collected throughout the hospitalization and that requires no data entry could be less costly and more informative. We have previously shown that the abnormal heart rate characteristics (HRC) of reduced variability and transient decelerations accompany neonatal illness such as late-onset sepsis. We hypothesized that more frequent and severe abnormal HRC are associated with an increased risk of death. We tested this hypothesis in two ways. Using data on infants older than 7 d of age, we first determined the association of the HRC index with death in the next week. Second, we devised a cumulative HRC score and determined its association with in-hospital death. There were 37 deaths in the 685 patients. The major findings were 1) the HRC index showed highly significant association with death in the succeeding 7 d (receiver-operating characteristic area > 0.7, p < 0.001), and 2) the cumulative HRC was highly significantly associated with neonatal in-hospital mortality (receiver-operating characteristic area > 0.80, p < 0.001). In both analyses, HRC added information to birth weight, gestational age, and postnatal age (p < 0.01). The HRC index provides independent information about the risk of neonatal death in the upcoming 7 d, and the cumulative HRC is an estimate of the risk of in-hospital neonatal mortality. |
| معلومات مُعتمدة: | NIGMS-64640 United States GM NIGMS NIH HHS |
| المشرفين على المادة: | 0 (Hemoglobins) |
| تواريخ الأحداث: | Date Created: 20040124 Date Completed: 20041108 Latest Revision: 20220311 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1203/01.PDR.0000119366.21770.9E |
| PMID: | 14739356 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0031-3998 |
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| DOI: | 10.1203/01.PDR.0000119366.21770.9E |