دورية أكاديمية
Subclasses of low-density lipoprotein and very low-density lipoprotein in familial combined hyperlipidemia: relationship to multiple lipoprotein phenotype.
| العنوان: | Subclasses of low-density lipoprotein and very low-density lipoprotein in familial combined hyperlipidemia: relationship to multiple lipoprotein phenotype. |
|---|---|
| المؤلفون: | Georgieva AM; Cardiovascular Research Institute Maastricht, Laboratory of Molecular Metabolism and Endocrinology, Department of Medicine, University of Maastricht, The Netherlands., van Greevenbroek MM, Krauss RM, Brouwers MC, Vermeulen VM, Robertus-Teunissen MG, van der Kallen CJ, de Bruin TW |
| المصدر: | Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2004 Apr; Vol. 24 (4), pp. 744-9. Date of Electronic Publication: 2004 Jan 29. |
| نوع المنشور: | Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 9505803 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1524-4636 (Electronic) Linking ISSN: 10795642 NLM ISO Abbreviation: Arterioscler Thromb Vasc Biol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 1998- : Baltimore, Md. : Lippincott Williams & Wilkins Original Publication: Dallas, TX : American Heart Association, c1995- |
| مواضيع طبية MeSH: | Hyperlipidemia, Familial Combined/*blood , Lipoproteins, LDL/*classification , Lipoproteins, VLDL/*classification, Adult ; Apolipoprotein A-I/blood ; Apolipoproteins E/blood ; Blood Protein Electrophoresis ; Female ; Humans ; Hypercholesterolemia/blood ; Hypercholesterolemia/genetics ; Hyperlipidemia, Familial Combined/genetics ; Hyperlipoproteinemia Type IV/blood ; Hyperlipoproteinemia Type IV/genetics ; Insulin/blood ; Lipoproteins, LDL/blood ; Lipoproteins, VLDL/blood ; Male ; Particle Size ; Phenotype |
| مستخلص: | Objective: The present study addresses the presence of distinct metabolic phenotypes in familial combined hyperlipidemia (FCHL) in relation to small dense low-density lipoprotein (sd LDL) and very low-density lipoprotein (VLDL) subclasses. Methods and Results: Hyperlipidemic FCHL relatives (n=72) were analyzed for LDL size by gradient gel electrophoresis. Pattern B LDL (sd LDL, particle size <258 A) and pattern A LDL (buoyant LDL, particle size > or =258 A) were defined. Analyses showed bimodal distribution of LDL size associated with distinct phenotypes. Subjects with predominantly large, buoyant LDL showed a hypercholesterolemic phenotype and the highest apo B levels. Subjects with predominantly sd LDL showed a hypertriglyceridemic, low high-density lipoprotein (HDL) cholesterol phenotype, with moderately elevated apoB, total cholesterol level, and LDL cholesterol level. Subjects with both buoyant LDL and sd LDL (pattern AB, n=7) showed an intermediate phenotype, with high normal plasma triglycerides. VLDL subfraction analysis showed that the sd LDL phenotype was associated with a 10-times higher number of VLDL1 particles of relatively lower apo AI and apo E content, as well as smaller VLDL2 particles, in combination with increased plasma insulin concentration in comparison to pattern A. Conclusions: The present observations underscore the importance of the VLDL triglyceride metabolic pathway in FCHL as an important determinant of the phenotypic heterogeneity of the disorder. |
| معلومات مُعتمدة: | HL-18574 United States HL NHLBI NIH HHS |
| المشرفين على المادة: | 0 (Apolipoprotein A-I) 0 (Apolipoproteins E) 0 (Insulin) 0 (Lipoproteins, LDL) 0 (Lipoproteins, VLDL) |
| تواريخ الأحداث: | Date Created: 20040131 Date Completed: 20040805 Latest Revision: 20111117 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1161/01.ATV.0000119681.47218.a4 |
| PMID: | 14751815 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1524-4636 |
|---|---|
| DOI: | 10.1161/01.ATV.0000119681.47218.a4 |