دورية أكاديمية
Experience-dependent immediate early gene expression in the adult central nervous system: evidence from enriched-environment studies.
| العنوان: | Experience-dependent immediate early gene expression in the adult central nervous system: evidence from enriched-environment studies. |
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| المؤلفون: | Pinaud R; Neurological Sciences Institute, Oregon Health & Science University, Portland, Oregon 97006, USA. pinaudr@nims.ohsu.edu |
| المصدر: | The International journal of neuroscience [Int J Neurosci] 2004 Mar; Vol. 114 (3), pp. 321-33. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 0270707 Publication Model: Print Cited Medium: Print ISSN: 0020-7454 (Print) Linking ISSN: 00207454 NLM ISO Abbreviation: Int J Neurosci Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Informa Healthcare Original Publication: New York, Gordon and Breach. |
| مواضيع طبية MeSH: | Environment* , Immediate-Early Proteins*, AIDS-Related Complex/*metabolism , Central Nervous System/*physiology , DNA-Binding Proteins/*metabolism , Gene Expression Regulation/*physiology , Transcription Factors/*metabolism, Animals ; Early Growth Response Protein 1 ; Humans ; Neuronal Plasticity/genetics ; Retina/metabolism |
| مستخلص: | Here I discuss evidence from our group's work that implicates the immediate early genes NGFI-A and arc as possible regulators of neuronal plasticity. The enriched environment (EE) paradigm has been demonstrated to induce neural plasticity in both developing and mature mammals. Others and we have recently demonstrated that adult rats placed within an enriched environment underwent central nervous system-wide increases in the expression levels for the IEGs NGFI-A and arc. The relationships between the altered expression profiles for both genes in response to an EE exposure, and their putative role in orchestrating network restructuring in response to enhanced environmental complexity are discussed. |
| Number of References: | 54 |
| المشرفين على المادة: | 0 (DNA-Binding Proteins) 0 (EGR1 protein, human) 0 (Early Growth Response Protein 1) 0 (Immediate-Early Proteins) 0 (Transcription Factors) |
| تواريخ الأحداث: | Date Created: 20040203 Date Completed: 20040322 Latest Revision: 20051117 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1080/00207450490264142 |
| PMID: | 14754658 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 0020-7454 |
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| DOI: | 10.1080/00207450490264142 |