دورية أكاديمية
Variability in the disposition of ibuprofen enantiomers in osteoarthritis patients.
| العنوان: | Variability in the disposition of ibuprofen enantiomers in osteoarthritis patients. |
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| المؤلفون: | Rudy AC; Department of Medicine, Indiana University School of Medicine, Indianapolis., Bradley JD, Ryan SI, Kalasinski LA, Xiaotao Q, Hall SD |
| المصدر: | Therapeutic drug monitoring [Ther Drug Monit] 1992 Dec; Vol. 14 (6), pp. 464-70. |
| نوع المنشور: | Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 7909660 Publication Model: Print Cited Medium: Print ISSN: 0163-4356 (Print) Linking ISSN: 01634356 NLM ISO Abbreviation: Ther Drug Monit Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Hagerstown, MD : Lippincott Williams & Wilkins Original Publication: [New York] Raven Press. |
| مواضيع طبية MeSH: | Ibuprofen/*pharmacokinetics , Osteoarthritis/*metabolism, Adult ; Aged ; Aged, 80 and over ; Dose-Response Relationship, Drug ; Double-Blind Method ; Drug Administration Schedule ; Female ; Humans ; Ibuprofen/administration & dosage ; Knee Joint ; Male ; Middle Aged ; Osteoarthritis/drug therapy ; Osteoarthritis, Hip/drug therapy ; Osteoarthritis, Hip/metabolism ; Stereoisomerism ; Tissue Distribution |
| مستخلص: | The pharmacokinetics of the enantiomers of ibuprofen have been investigated following oral administration of 300 or 600 mg of racemic ibuprofen four times daily to 45 patients with osteoarthritis. Fifteen of these patients also received single doses of 300 or 600 mg of racemic ibuprofen. Serum concentrations of R- and S-ibuprofen and urine concentrations of the stereoisomers of ibuprofen and its metabolites were measured by high-performance liquid chromatography. The fraction inverted (F(inv)) of the inactive R- to active S-ibuprofen was estimated by a urinary metabolite method. For the 15 patients in both the chronic and single dose studies, there were no significant differences in the clearance of R-ibuprofen or F(inv). The elimination half-lives of R- and S-ibuprofen were comparable for the single and chronic dosing studies. The area under the curve (AUC) values, 6-h trough concentrations, and average steady state concentrations of the R- and S-enantiomers were statistically different after chronic dosing. Despite considerable variability in the clearances in these patients, e.g., clearance (CL) of R-ibuprofen showed 28-49% CV, much less variability was seen in F(inv) (range 9-19% CV), implying that patients would receive similar effective doses of active S-ibuprofen in spite of large differences in kinetics. |
| معلومات مُعتمدة: | AR39250 United States AR NIAMS NIH HHS |
| المشرفين على المادة: | WK2XYI10QM (Ibuprofen) |
| تواريخ الأحداث: | Date Created: 19921201 Date Completed: 19930218 Latest Revision: 20190902 |
| رمز التحديث: | 20240627 |
| DOI: | 10.1097/00007691-199212000-00005 |
| PMID: | 1485367 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0163-4356 |
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| DOI: | 10.1097/00007691-199212000-00005 |