دورية أكاديمية
[The pathogenesis of psoriasis. Autoradiographic in vitro studies on cell proliferation in psoriasis vulgaris and other normal and hyperproliferative states of epidermal and dermal human cells].
| العنوان: | [The pathogenesis of psoriasis. Autoradiographic in vitro studies on cell proliferation in psoriasis vulgaris and other normal and hyperproliferative states of epidermal and dermal human cells]. |
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| عنوان ترانسليتريتد: | Zur Pthogenese der Psoriasis Autoradiographische in vitro-Untersuchungen zur Zellproliferation bei der Psoriasis vulgaris sowie bei anderen normalen und hyperproliferativen Zuständen epidermaler und dermaler Zellen des Menschen. |
| المؤلفون: | Pullman H |
| المصدر: | Fortschritte der Medizin [Fortschr Med] 1978 Jul 06; Vol. 96 (25), pp. 1335-8. |
| نوع المنشور: | English Abstract; Journal Article; Review |
| اللغة: | German |
| بيانات الدورية: | Publisher: Urban Und Vogel Country of Publication: Germany NLM ID: 2984763R Publication Model: Print Cited Medium: Print ISSN: 0015-8178 (Print) Linking ISSN: 00158178 NLM ISO Abbreviation: Fortschr Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Munchen : Urban Und Vogel Original Publication: Munich, [etc.], Verlag Fortschritte der Medizin. |
| مواضيع طبية MeSH: | Psoriasis/*etiology, Autoradiography ; Cell Division ; DNA/biosynthesis ; Dermatitis, Contact/physiopathology ; Drug Eruptions/physiopathology ; Eczema/physiopathology ; Epidermis/pathology ; Humans ; Thymidine/metabolism |
| مستخلص: | In the epidermal cells of patients suffering from psoriasis we found a significant prolongation of DNA-synthesis time (ts) in uninvolved skin, very early lesions, and fully developed plaques. In uninvolved psoriatic skin ts in addition increased significantly within 6 hours after stripping of the horny layer. In normal epidermis and in other states of epidermal inflammation and hyperproliferation (akanthosis by petrolatum, toxic dermatitis, chronic allergic ekzema, neurodermitis, allergic patch test reaction) a comparable prolongation of ts was not ascertainable. This prolongation is most distinct in the early lesions and proceeds the development of hyperproliferation and akanthosis. A dermal infiltrate with increased proliferative activity seems to be a stimulus, in the sense of a Koebner-phenomenon. The abnormal psoriatic epidermis, with disturbed DNA-synthesis, reacts to this infiltrate as well as to other irritants not with a limited hyperproliferation but with the development of psoriatic plaque. |
| المشرفين على المادة: | 9007-49-2 (DNA) VC2W18DGKR (Thymidine) |
| تواريخ الأحداث: | Date Created: 19780706 Date Completed: 19780915 Latest Revision: 20131121 |
| رمز التحديث: | 20221213 |
| PMID: | 149749 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0015-8178 |
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