دورية أكاديمية
Improvement of renal preservation by adding lidoflazine to University of Wisconsin solution. An experimental study in the rat.
| العنوان: | Improvement of renal preservation by adding lidoflazine to University of Wisconsin solution. An experimental study in the rat. |
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| المؤلفون: | Jacobsson J; Department of Urology, University Hospital, Uppsala, Sweden., Odlind B, Tufveson G, Wahlberg J |
| المصدر: | Cryobiology [Cryobiology] 1992 Jun; Vol. 29 (3), pp. 305-9. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0006252 Publication Model: Print Cited Medium: Print ISSN: 0011-2240 (Print) Linking ISSN: 00112240 NLM ISO Abbreviation: Cryobiology Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2000- > : Amsterdam : Elsevier Original Publication: San Diego, CA : Academic Press |
| مواضيع طبية MeSH: | Kidney*/blood supply , Kidney*/injuries , Lidoflazine* , Organ Preservation Solutions* , Solutions*, Organ Preservation/*methods, Adenosine ; Allopurinol ; Animals ; Cold Temperature ; Erythrocytes ; Glutathione ; Insulin ; Kidney Transplantation ; Male ; Raffinose ; Rats ; Rats, Inbred Strains ; Reperfusion Injury/prevention & control |
| مستخلص: | The purpose of this study was to investigate the possibility of improving the organ preservation properties of the University of Wisconsin (UW) solution by adding the calcium entry blocker lidoflazine. We also investigated the possibility of decreasing the cold ischemia and reperfusion damage by pretreatment with lidoflazine of the donor and/or recipient. The protective effects of lidoflazine treatment were estimated by measuring the amount of trapped erythrocytes in the rat renal medulla after 48 h of cold storage, subsequent transplantation, and 20 min of reperfusion. Lidoflazine (20 mg/liter) added to the UW solution decreased the amount of erythrocyte trapping from 14.8 +/- 3.1% in controls to 8.6 +/- 1.7% (P less than 0.01). The flow rate of the flush-out solution during the harvesting procedure was also significantly (P less than 0.01) increased when lidoflazine was included in the UW solution (1.10 +/- 0.21 ml/min vs 0.75 +/- 0.22 ml/min). Administration of lidoflazine (0.28 mg/kg body wt) to the donor and/or the recipient did not further reduce the postischemia/reperfusion damage as estimated by the degree of erythrocyte trapping. In conclusion, the results indicate that the preservation properties of the UW solution can be significantly improved by adding lidoflazine to the solution. |
| المشرفين على المادة: | 0 (Insulin) 0 (Organ Preservation Solutions) 0 (Solutions) 0 (University of Wisconsin-lactobionate solution) 63CZ7GJN5I (Allopurinol) GAN16C9B8O (Glutathione) J4ZHN3HBTE (Lidoflazine) K72T3FS567 (Adenosine) N5O3QU595M (Raffinose) |
| تواريخ الأحداث: | Date Created: 19920601 Date Completed: 19920914 Latest Revision: 20220311 |
| رمز التحديث: | 20240627 |
| DOI: | 10.1016/0011-2240(92)90031-v |
| PMID: | 1499315 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0011-2240 |
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| DOI: | 10.1016/0011-2240(92)90031-v |