دورية أكاديمية
Acute vascular humoral rejection in a sensitized cardiac graft recipient: diagnostic value of C4d immunofluorescence.
| العنوان: | Acute vascular humoral rejection in a sensitized cardiac graft recipient: diagnostic value of C4d immunofluorescence. |
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| المؤلفون: | Duong Van Huyen JP; Department of Pathology, Unit of Cardiac Transplantation, Hôpital Européen Georges Pompidou, Paris, France., Fornes P, Guillemain R, Amrein C, Chevalier P, Latremouille C, Creput C, Glotz D, Nochy D, Bruneval P |
| المصدر: | Human pathology [Hum Pathol] 2004 Mar; Vol. 35 (3), pp. 385-8. |
| نوع المنشور: | Case Reports; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: W B Saunders Country of Publication: United States NLM ID: 9421547 Publication Model: Print Cited Medium: Print ISSN: 0046-8177 (Print) Linking ISSN: 00468177 NLM ISO Abbreviation: Hum Pathol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Philadelphia, PA : W B Saunders Original Publication: Philadelphia, W B. Saunders Co. |
| مواضيع طبية MeSH: | CD4 Antigens*/metabolism, Coronary Vessels/*pathology , Graft Rejection/*pathology , Heart Transplantation/*pathology, Acute Disease ; Adult ; Biomarkers/analysis ; Coronary Vessels/immunology ; Coronary Vessels/metabolism ; Endocardium/immunology ; Endocardium/metabolism ; Endocardium/pathology ; Endothelium, Vascular/immunology ; Endothelium, Vascular/metabolism ; Endothelium, Vascular/pathology ; Female ; Fluorescent Antibody Technique ; Graft Rejection/immunology ; Graft Rejection/metabolism ; Heart Transplantation/adverse effects ; Heart Transplantation/immunology ; Humans ; Transplantation, Homologous |
| مستخلص: | A 37-year-old female patient had a cardiac transplantation for dilated cardiomyopathy. She was sensitized by two pregnancies showing anti-human leukocyte antigen I and II antibodies. The pretransplantation crossmatch was negative, but she developed acute humoral rejection characterized by vascular C4d deposits, arteriolitis, and intravascular leukocyte accumulation and adhesion in venules. Although C4d deposits disappeared in 4 weeks, she had persistent endothelial cell activation (endothelial expression of ELAM-1, VCAM-1, or human leukocyte antigen class II) throughout the 6 months of follow-up. Although she received intensive immunosuppression, she presented three episodes of acute cellular rejection during that period of time. This case shows that C4d deposits represent a sensitive marker of acute humoral rejection in cardiac transplantation. Therefore, C4d immunofluorescence should be more frequently assessed in endomyocardial biopsies. |
| المشرفين على المادة: | 0 (Biomarkers) 0 (CD4 Antigens) |
| تواريخ الأحداث: | Date Created: 20040316 Date Completed: 20040414 Latest Revision: 20190722 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.humpath.2003.10.016 |
| PMID: | 15017599 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0046-8177 |
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| DOI: | 10.1016/j.humpath.2003.10.016 |