دورية أكاديمية
[In vivo anti-tumor effect of polysaccharide from Sargassum confusum and the mechanisms].
| العنوان: | [In vivo anti-tumor effect of polysaccharide from Sargassum confusum and the mechanisms]. |
|---|---|
| المؤلفون: | Liu QY; Analytical Center, Guangdong Medical College, Zhanjiang 524023, China. liuqy2001@sohu.com, Meng QY |
| المصدر: | Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA [Di Yi Jun Yi Da Xue Xue Bao] 2004 Apr; Vol. 24 (4), pp. 434-6. |
| نوع المنشور: | English Abstract; Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | Chinese |
| بيانات الدورية: | Publisher: Di 1 jun yi da xue Country of Publication: China NLM ID: 9426110 Publication Model: Print Cited Medium: Print ISSN: 1000-2588 (Print) Linking ISSN: 10002588 NLM ISO Abbreviation: Di Yi Jun Yi Da Xue Xue Bao Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Guangzhou Shi Tonghe Zhen : Di 1 jun yi da xue, -2005. |
| مواضيع طبية MeSH: | Adjuvants, Immunologic/*pharmacology , Antineoplastic Agents/*pharmacology , Antioxidants/*pharmacology , Polysaccharides/*pharmacology , Sargassum/*chemistry, Animals ; Female ; Lipid Peroxidation/drug effects ; Male ; Mice ; Polysaccharides/therapeutic use ; Sarcoma 180/drug therapy |
| مستخلص: | Objective: To study the anti-tumor effects of polysaccharide from Sargassum confusum in mice and explore the possible mechanisms. Methods Forty-five mice bearing transplanted tumor S180 were used to study the effects of polysaccharide on the tumor weight, thymus gland and spleen. The changes in serum contents of SOD, glutathione peroxidase (GSH-PX) activity and malondialdehyde (MDA) content were assayed. Results: The polysaccharide from Sargassum confusum significantly inhibited the growth of S180 tumor in mice and enhanced the functions of the immune organs. SOD content and GSH-PX activity were significantly increased from 350.76+/-31.34 NU/ml, 299.36+/-43.63 U to 487.76+/-16.67 NU/ml,370.90+/-16.49 U(P<0.01), MDA content decreased from 9.46+/-1.77 nmol/ml to 7.26+/-1.18 nmol/ml in the serum after polysaccharide treatment. Conclusion: The anti-tumor effect of the polysaccharide from Sargassum confusum can be attributed to improve functions of the immune organs and enhance anti-oxidative capacity in tumor-bearing mice. |
| المشرفين على المادة: | 0 (Adjuvants, Immunologic) 0 (Antineoplastic Agents) 0 (Antioxidants) 0 (Polysaccharides) |
| تواريخ الأحداث: | Date Created: 20040420 Date Completed: 20040722 Latest Revision: 20240109 |
| رمز التحديث: | 20240109 |
| PMID: | 15090317 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1000-2588 |
|---|