دورية أكاديمية
Second malignant neoplasms in childhood acute lymphoblastic leukemia: primitive neuroectodermal tumor of the chest wall with germline p53 mutation as a second malignant neoplasm.
| العنوان: | Second malignant neoplasms in childhood acute lymphoblastic leukemia: primitive neuroectodermal tumor of the chest wall with germline p53 mutation as a second malignant neoplasm. |
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| المؤلفون: | Suarez CR; Department of Pediatrics, Section of Hematology/Oncology, University of Louisville School of Medicine, Louisville, Kentucky, USA. csuarez@psm.edu, Bertolone SJ, Raj AB, Coventry S |
| المصدر: | American journal of hematology [Am J Hematol] 2004 May; Vol. 76 (1), pp. 52-6. |
| نوع المنشور: | Case Reports; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Blackwell Country of Publication: United States NLM ID: 7610369 Publication Model: Print Cited Medium: Print ISSN: 0361-8609 (Print) Linking ISSN: 03618609 NLM ISO Abbreviation: Am J Hematol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: New York Ny : Wiley-Blackwell Original Publication: New York, Liss. |
| مواضيع طبية MeSH: | Antineoplastic Combined Chemotherapy Protocols/*therapeutic use , Neoplasms, Second Primary/*genetics , Neuroectodermal Tumors, Primitive, Peripheral/*genetics , Precursor Cell Lymphoblastic Leukemia-Lymphoma/*drug therapy , Thoracic Wall/*pathology , Tumor Suppressor Protein p53/*genetics, Child, Preschool ; Combined Modality Therapy ; Humans ; Male ; Mutation ; Neoplasms, Second Primary/pathology ; Neoplasms, Second Primary/therapy ; Neuroectodermal Tumors, Primitive, Peripheral/pathology ; Neuroectodermal Tumors, Primitive, Peripheral/therapy ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/pathology ; Thoracic Wall/metabolism ; Treatment Outcome |
| مستخلص: | About 80% of children treated for acute lymphoblastic leukemia (ALL) will be long-term survivors. Second malignant neoplasm (SMNs) are a devastating sequelae observed on these children, with an estimated cumulative risk of 2-3.3% fifteen years after diagnosis. Primitive neuroectodermal tumor of bone (PNET) is rarely observed as a SMN following treatment of childhood ALL. The authors described the occurrence of a chest wall PNET of the bone at the site of a central line placement associated with both germ-line and tumor cell p53 mutation in a 8-year-old boy 1 year after completing therapy for standard risk ALL. A review of the literature of 25,051 children treated for ALL discovered 230 SMNs (0.99%), and only one case of PNET of the bone was noted among this group. The occurrence of a SMN in children treated for ALL is a rare event. Such an occurrence, in particular the development of an unusual SMN, should be evaluated for a germline p53 mutation. (Copyright 2004 Wiley-Liss, Inc.) |
| المشرفين على المادة: | 0 (Tumor Suppressor Protein p53) |
| تواريخ الأحداث: | Date Created: 20040429 Date Completed: 20040603 Latest Revision: 20071115 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1002/ajh.20012 |
| PMID: | 15114597 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0361-8609 |
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| DOI: | 10.1002/ajh.20012 |