دورية أكاديمية
[Important prognostic significance of a sentinel-node biopsy in patients with malignant melanoma].
| العنوان: | [Important prognostic significance of a sentinel-node biopsy in patients with malignant melanoma]. |
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| عنوان ترانسليتريتد: | Belangrijke prognostische betekenis van schildwachtklierbiopsie bij patiënten met maligne melanoom. |
| المؤلفون: | Keijzer R; Afd. Chirurgie: hr.dr.R.Keijzer, Reinier de Graaf Groep, Reinier de Graafweg 3-11, 2625 AD Delft. keijzer@rdgg.nl, Bril H, van der Loo EM, de Graaf PW |
| المصدر: | Nederlands tijdschrift voor geneeskunde [Ned Tijdschr Geneeskd] 2004 May 01; Vol. 148 (18), pp. 884-8. |
| نوع المنشور: | English Abstract; Journal Article |
| اللغة: | Dutch; Flemish |
| بيانات الدورية: | Publisher: Vereniging NTvG Country of Publication: Netherlands NLM ID: 0400770 Publication Model: Print Cited Medium: Print ISSN: 0028-2162 (Print) Linking ISSN: 00282162 NLM ISO Abbreviation: Ned Tijdschr Geneeskd Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2017?-: Amsterdam : Vereniging NTvG Original Publication: Houten : Bohn Stafleu van Loghum |
| مواضيع طبية MeSH: | Sentinel Lymph Node Biopsy*, Lymph Nodes/*pathology , Melanoma/*pathology , Skin Neoplasms/*pathology, Adolescent ; Adult ; Aged ; Aged, 80 and over ; Child ; Female ; Humans ; Lymphatic Metastasis ; Male ; Melanoma/diagnosis ; Melanoma/mortality ; Middle Aged ; Neoplasm Recurrence, Local ; Neoplasm Staging ; Netherlands ; Prognosis ; Retrospective Studies ; Skin Neoplasms/diagnosis ; Skin Neoplasms/mortality ; Survival Analysis ; Treatment Outcome |
| مستخلص: | Objective: To determine the prognostic significance of sentinel-node biopsy in patients with malignant melanoma (unlike the United States, a sentinel-node biopsy is still not routinely performed on melanoma patients in the Netherlands, as the outcomes of prospectively randomised clinical trials are being awaited). Design: Retrospective. Methods: Between 1996 and 2001 a sentinel-node biopsy and a re-excision of the scar of the diagnostic biopsy were performed on all melanoma patients who had a Breslow thickness > or = 1 mm or a Clark level > or = IV. At operation the sentinel node was identified with a gamma probe and patent blue. It was removed and sent for pathological investigation for the presence of melanoma cells. If the sentinel node was tumour positive, a dissection of the regional lymph-node basin was performed. Subsequently, these patients were put forward for the European Organisation for Research and Treatment of Cancer (EORTC) peginterferon alfa(2b) adjuvant treatment study. Results: A sentinel-node biopsy was performed in 61 lymphnode basins in 57 patients (18 male and 39 female; median age: 45 years (range: 9-80)). The median Breslow thickness of the melanomas was 2.2 mm (range: 0.7-13 mm). In 10 of the 61 cases histological examination of the sentinel node demonstrated tumour cells. In 2 additional cases tumour cells were demonstrated only by immunohistochemical studies or complete dissection of the node. Eight regional lymph-node basins were dissected, two of which contained additional metastases. The median follow-up was 36 months (range: 1-68). During follow-up 12 of the 57 patients were found to have metastases, in 8 of these patients the sentinel-node biopsy contained tumour cells. The negative predictive value of a tumourless sentinel node with respect to the later occurrence of distant metastases was 92%. Conclusion: The patients with a tumour-positive sentinel node had a poorer prognosis with respect to distant metastases than patients with a tumour-negative node. This is the main reason for performing sentinel-node biopsy: to predict the prognosis of the disease. Therefore sentinel-node biopsy should be incorporated into the treatment of patients with malignant melanoma. |
| التعليقات: | Comment in: Ned Tijdschr Geneeskd. 2004 Jun 26;148(26):1311-2; author reply 1312. (PMID: 15279220) Comment in: Ned Tijdschr Geneeskd. 2004 Aug 28;148(35):1749-50; author reply 1750. (PMID: 15468908) Comment in: Ned Tijdschr Geneeskd. 2004 Sep 25;148(39):1941-2. (PMID: 15495996) |
| تواريخ الأحداث: | Date Created: 20040522 Date Completed: 20040617 Latest Revision: 20061115 |
| رمز التحديث: | 20240628 |
| PMID: | 15152391 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0028-2162 |
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