دورية أكاديمية
Eudragit RL100 nanoparticle system for the ophthalmic delivery of cloricromene.
| العنوان: | Eudragit RL100 nanoparticle system for the ophthalmic delivery of cloricromene. |
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| المؤلفون: | Bucolo C; Bausch & Lomb Oftal, C. so Italia 141, I-95127, Catania, Italy., Maltese A, Maugeri F, Busà B, Puglisi G, Pignatello R |
| المصدر: | The Journal of pharmacy and pharmacology [J Pharm Pharmacol] 2004 Jul; Vol. 56 (7), pp. 841-6. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 0376363 Publication Model: Print Cited Medium: Print ISSN: 0022-3573 (Print) Linking ISSN: 00223573 NLM ISO Abbreviation: J Pharm Pharmacol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2021- : [Oxford] : Oxford University Press Original Publication: London : Pharmaceutical Society of Great Britain |
| مواضيع طبية MeSH: | Acrylic Resins/*chemistry , Chromonar/*administration & dosage , Chromonar/*analogs & derivatives , Chromonar/*chemistry , Platelet Aggregation Inhibitors/*administration & dosage , Platelet Aggregation Inhibitors/*chemistry, Animals ; Area Under Curve ; Chromatography, High Pressure Liquid ; Chromonar/pharmacokinetics ; Drug Administration Routes ; Drug Delivery Systems ; Drug Stability ; Male ; Nanotechnology ; Particle Size ; Platelet Aggregation Inhibitors/pharmacokinetics ; Rabbits ; Solubility ; Surface Properties ; Technology, Pharmaceutical |
| مستخلص: | A Eudragit RL100 polymer nanoparticle system loaded with cloricromene was prepared and characterized on the basis of physicochemical properties, stability and drug release features. To investigate the ocular bioavailability of cloricromene after inclusion in the polymer matrix, the new nanoparticle system was topically administered in the rabbit eye and compared with an aqueous solution of the same drug. The nanoparticle system showed interesting size distribution and surface charge values, suitable for ophthalmic application. The results indicated that the dispersion of cloricromene within Eudragit RL100 polymer nanoparticles increased its ocular bioavailability and enhanced the biopharmaceutical profile. The new cloricromene-loaded nanoparticle system described here may be useful in clinical practice. |
| المشرفين على المادة: | 0 (Acrylic Resins) 0 (Platelet Aggregation Inhibitors) 33434-24-1 (Eudragit RS) B9454PE93C (cloricromen) R0C9NIE5JJ (Chromonar) |
| تواريخ الأحداث: | Date Created: 20040706 Date Completed: 20041103 Latest Revision: 20141120 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1211/0022357023835 |
| PMID: | 15233861 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0022-3573 |
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| DOI: | 10.1211/0022357023835 |