دورية أكاديمية
An audit of the efficacy of the oral brush biopsy technique in a specialist Oral Medicine unit.
| العنوان: | An audit of the efficacy of the oral brush biopsy technique in a specialist Oral Medicine unit. |
|---|---|
| المؤلفون: | Poate TW; Oral Medicine, Division of Maxillofacial Diagnostic, Medical and Surgical Sciences, Eastman Dental Institute for Oral Health Care Sciences, UCL, University of London, 256 Gray's Inn Road, London WC1X 8LD, UK., Buchanan JA, Hodgson TA, Speight PM, Barrett AW, Moles DR, Scully C, Porter SR |
| المصدر: | Oral oncology [Oral Oncol] 2004 Sep; Vol. 40 (8), pp. 829-34. |
| نوع المنشور: | Evaluation Study; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: England NLM ID: 9709118 Publication Model: Print Cited Medium: Print ISSN: 1368-8375 (Print) Linking ISSN: 13688375 NLM ISO Abbreviation: Oral Oncol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Amsterdam : Elsevier Original Publication: Oxford ; New York : Pergamon, c1997- |
| مواضيع طبية MeSH: | Biopsy/*methods , Carcinoma, Squamous Cell/*pathology , Medical Audit/*methods , Mouth Neoplasms/*pathology, Adult ; Aged ; Aged, 80 and over ; Diagnosis, Computer-Assisted ; Female ; Humans ; Male ; Middle Aged ; Predictive Value of Tests ; Retrospective Studies ; Sensitivity and Specificity |
| مستخلص: | The diagnosis of oral epithelial dysplasia has traditionally been based upon histopathological evaluation of a full thickness biopsy specimen from lesional tissue. It has recently been proposed that cytological examination of "brush biopsy" samples is a non-invasive method of determining the presence of cellular atypia, and hence the likelihood of oral epithelial dysplasia. The present audit determined, retrospectively the sensitivity, specificity and positive and negative predictive values of the oral brush biopsy technique in the diagnosis of potentially malignant disease in a group of 112 patients attending a specialist Oral Medicine unit. The sensitivity of detection of oral epithelial dysplasia or squamous cell carcinoma of the oral brush biopsy system was 71.4% while the specificity was 32%. The positive predictive value of an abnormal brush biopsy result (positive or atypical) was 44.1%, while the negative predictive value was 60%. It is concluded that not all potentially malignant disease is detected with this non-invasive investigative procedure. |
| التعليقات: | Comment in: Oral Oncol. 2005 Aug;41(7):753-5; author reply 756. (PMID: 15936979) |
| تواريخ الأحداث: | Date Created: 20040804 Date Completed: 20041102 Latest Revision: 20191210 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.oraloncology.2004.02.005 |
| PMID: | 15288839 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1368-8375 |
|---|---|
| DOI: | 10.1016/j.oraloncology.2004.02.005 |