دورية أكاديمية
[The study of peptide effect in the mechanisms of angiogenesis and forming of microenvironment of the tumors in old rats].
| العنوان: | [The study of peptide effect in the mechanisms of angiogenesis and forming of microenvironment of the tumors in old rats]. |
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| عنوان ترانسليتريتد: | Issledovanie roli peptidov v mekhanizmakh angiogeneza i formirovaniia mikrookruzheniia opukholeĭ u starykh krys. |
| المؤلفون: | Barykina OP, Iuzhakov VV, Chalisova NI |
| المصدر: | Advances in gerontology = Uspekhi gerontologii [Adv Gerontol] 2004; Vol. 13, pp. 130-42. |
| نوع المنشور: | Journal Article |
| اللغة: | Russian |
| بيانات الدورية: | Publisher: Ėskulap Country of Publication: Russia (Federation) NLM ID: 100971443 Publication Model: Print Cited Medium: Print ISSN: 1561-9125 (Print) Linking ISSN: 15619125 NLM ISO Abbreviation: Adv Gerontol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Sankt-Peterburg : Ėskulap, |
| مواضيع طبية MeSH: | Angiogenesis Inhibitors/*therapeutic use , Antineoplastic Agents/*therapeutic use , Dipeptides/*therapeutic use , Epidermal Growth Factor/*therapeutic use , Neovascularization, Pathologic/*drug therapy , Sarcoma, Experimental/*drug therapy, Animals ; Apoptosis ; EGF Family of Proteins ; Epigen ; Hindlimb/blood supply ; Male ; Necrosis ; Neoplasm Transplantation ; Rats ; Rats, Inbred Strains ; Sarcoma, Experimental/blood supply |
| مستخلص: | The experiments were performed in rats with transplanted sarkoma M-1. The injections of synthetic peptide vilon at the doses 0.5 mcg sigificantly increased the apoptosis of tumor cells in the experiment as compared to the control group. So vilon has possessed the oncomodulating action on the transplanted carcinoma. The injections of epigene lead to the inhibition of the sarcoma growth due to the development of the hemorragic necrosis and apoptosis increased. The results obtained suggested that vilon and epigene are the perspective preparates in the cancer therapy. |
| المشرفين على المادة: | 0 (Angiogenesis Inhibitors) 0 (Antineoplastic Agents) 0 (Dipeptides) 0 (EGF Family of Proteins) 0 (Epgn protein, rat) 0 (Epigen) 62229-50-9 (Epidermal Growth Factor) H34V7IM5ML (lysylglutamic acid) |
| تواريخ الأحداث: | Date Created: 20041020 Date Completed: 20050502 Latest Revision: 20171116 |
| رمز التحديث: | 20240628 |
| PMID: | 15490736 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1561-9125 |
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