دورية أكاديمية
Hypertension: cardiovascular implications in a cohort of old old.
| العنوان: | Hypertension: cardiovascular implications in a cohort of old old. |
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| المؤلفون: | Guzik HJ; Department of Medicine, Albert Einstein College of Medicine, Bronx, New York., Ooi WL, Frishman WH, Greenberg S, Aronson MK |
| المصدر: | Journal of the American Geriatrics Society [J Am Geriatr Soc] 1992 Apr; Vol. 40 (4), pp. 348-53. |
| نوع المنشور: | Journal Article; Research Support, U.S. Gov't, P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Blackwell Science Country of Publication: United States NLM ID: 7503062 Publication Model: Print Cited Medium: Print ISSN: 0002-8614 (Print) Linking ISSN: 00028614 NLM ISO Abbreviation: J Am Geriatr Soc Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Malden, MA : Blackwell Science Original Publication: New York [etc.] |
| مواضيع طبية MeSH: | Aged, 80 and over*, Cardiovascular Diseases/*epidemiology , Hypertension/*complications, Age Factors ; Aged ; Antihypertensive Agents/therapeutic use ; Blood Pressure ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/mortality ; Cause of Death ; Female ; Hospitals, University ; Humans ; Hypertension/classification ; Hypertension/epidemiology ; Incidence ; Male ; Medical History Taking ; New York City/epidemiology ; Population Surveillance ; Predictive Value of Tests ; Prevalence ; Proportional Hazards Models ; Prospective Studies ; Risk Factors ; Survival Analysis |
| مستخلص: | Objective: To examine the prevalence and cardiovascular implications of hypertension in advanced age. Design: Prospective non-interventional study of a fixed cohort of very elderly subjects. Participants and Setting: The subjects were 488 community-dwelling volunteers. Mean age at entry was 79 years (range 75-85). All subjects were ambulatory, non-demented, and free of terminal illness at baseline. Participants were evaluated at the gerontology department of an urban medical school. Main Outcome Measures: Cardiovascular morbid and mortal events that were followed included fatal and non-fatal myocardial infarction, fatal and non-fatal stroke, and death. Prevalence of unrecognized myocardial infarction defined by electrocardiographic changes was also assessed. Results: When hypertension was defined by history, current use of medications, or measured elevations in blood pressure, 78% of the subjects could be considered hypertensive. Univariate analysis showed an increased incidence of strokes in subjects with measured hypertension (P = 0.04). Subjects with elevated blood pressure (untreated) were more likely to develop clinically unrecognized myocardial infarction (P = 0.017). Multivariate survival analysis showed hypertension to be a modest predictor of overall cardiovascular disease (P = 0.067) but not of all-cause mortality. Left ventricular hypertrophy was a predictor of cardiovascular disease (P = 0.013) and all-cause mortality (P = 0.008). Age remained a significant risk factor for these endpoints, even in the very old. Isolated systolic hypertension was analyzed separately and in univariate analysis was a risk factor for stroke but not other cardiovascular morbidity. Conclusions: Hypertension at advanced age remains a modestly important risk factor in the development of cardiovascular disease. |
| معلومات مُعتمدة: | NS 19234 United States NS NINDS NIH HHS |
| المشرفين على المادة: | 0 (Antihypertensive Agents) |
| تواريخ الأحداث: | Date Created: 19920401 Date Completed: 19920501 Latest Revision: 20190709 |
| رمز التحديث: | 20240627 |
| DOI: | 10.1111/j.1532-5415.1992.tb02133.x |
| PMID: | 1556362 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0002-8614 |
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| DOI: | 10.1111/j.1532-5415.1992.tb02133.x |