دورية أكاديمية
[Biotechnological synthesis of ribavirin. Effect of ribavirin and its various combinations on the reproduction of Vaccinia virus].
| العنوان: | [Biotechnological synthesis of ribavirin. Effect of ribavirin and its various combinations on the reproduction of Vaccinia virus]. |
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| عنوان ترانسليتريتد: | Biotekhnologicheskiĭ sposob polucheniia ribavirina. Deĭstvie ribavirina i nekotorykh ego kombinatsiĭ na reproduktsiiu virusa ospovaktsiny (Vaccinia virus). |
| المؤلفون: | Konstantinova ID, Leont'eva NA, Galegov GA, Ryzhova OI, Chuvikovskiĭ DV, Antonov KV, Esipov RS, Taran SA, Verevkina KN, Feofanov SA, Miroshnikov AI |
| المصدر: | Bioorganicheskaia khimiia [Bioorg Khim] 2004 Nov-Dec; Vol. 30 (6), pp. 613-20. |
| نوع المنشور: | Journal Article |
| اللغة: | Russian |
| بيانات الدورية: | Publisher: Nauka Country of Publication: Russia (Federation) NLM ID: 7804941 Publication Model: Print Cited Medium: Print ISSN: 0132-3423 (Print) Linking ISSN: 01323423 NLM ISO Abbreviation: Bioorg Khim Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Moskva, Nauka |
| مواضيع طبية MeSH: | Antiviral Agents/*chemical synthesis , Nucleosides/*chemical synthesis , Ribavirin/*analogs & derivatives , Ribavirin/*chemical synthesis , Vaccinia virus/*drug effects, Animals ; Antiviral Agents/pharmacology ; Azauridine/analogs & derivatives ; Azauridine/chemical synthesis ; Azauridine/pharmacology ; Catalysis ; Chlorocebus aethiops ; Drug Interactions ; Enzymes, Immobilized ; Nucleosides/pharmacology ; Purine-Nucleoside Phosphorylase/chemistry ; Ribavirin/pharmacology ; Uridine Phosphorylase/chemistry ; Vero Cells ; Vidarabine/analogs & derivatives ; Vidarabine/chemical synthesis ; Vidarabine/pharmacology ; Virus Replication/drug effects |
| مستخلص: | The biotechnological method of synthesis of ribavirin, vidarabin, and 6-azauridine by the use of immobilized recombinant enzymatic preparations of nucleoside phosphorylase was improved. The effect of ribavirin and its combinations with the other synthesized nucleosides on the reproduction of Vaccinia virus was studied using cultures of Vero cells. The combination of ribavirin and vidarabin was shown to provide an antiviral effect at lesser concentrations than when these compounds were taken separately. The English version of the paper: Russian Journal of Bioorganic Chemistry, 2004, vol. 30, no. 6; see also http://www.maik.ru. |
| المشرفين على المادة: | 0 (Antiviral Agents) 0 (Enzymes, Immobilized) 0 (Nucleosides) 49717AWG6K (Ribavirin) 7BVB29RCPR (Azauridine) EC 2.4.2.1 (Purine-Nucleoside Phosphorylase) EC 2.4.2.3 (Uridine Phosphorylase) FA2DM6879K (Vidarabine) |
| تواريخ الأحداث: | Date Created: 20041214 Date Completed: 20050513 Latest Revision: 20191210 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1023/b:rubi.0000049772.18675.34 |
| PMID: | 15586813 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0132-3423 |
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| DOI: | 10.1023/b:rubi.0000049772.18675.34 |