دورية أكاديمية
Absence of constitutional Y chromosome AZF deletions in patients with testicular germ cell tumors.
| العنوان: | Absence of constitutional Y chromosome AZF deletions in patients with testicular germ cell tumors. |
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| المؤلفون: | Lutke Holzik MF; Department of Surgical Oncology, Groningen University Medical Center, Groningen, The Netherlands., Storm K, Sijmons RH, D'hollander M, Arts EG, Verstraaten ML, Sleijfer DT, Hoekstra HJ |
| المصدر: | Urology [Urology] 2005 Jan; Vol. 65 (1), pp. 196-201. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: United States NLM ID: 0366151 Publication Model: Print Cited Medium: Internet ISSN: 1527-9995 (Electronic) Linking ISSN: 00904295 NLM ISO Abbreviation: Urology Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: New York : Elsevier Science Original Publication: Ridgewood, N.J., Professional Medical Services Co. |
| مواضيع طبية MeSH: | Chromosome Deletion*, Chromosomes, Human, Y/*ultrastructure , Germinoma/*genetics , Infertility, Male/*etiology , Seminal Plasma Proteins/*genetics , Testicular Neoplasms/*genetics, Cryptorchidism/genetics ; DNA Mutational Analysis ; Genetic Loci ; Germinoma/complications ; Humans ; Infertility, Male/genetics ; Lymphocytes/chemistry ; Male ; Oligospermia/etiology ; Oligospermia/genetics ; Polymerase Chain Reaction ; Seminoma/complications ; Seminoma/genetics ; Testicular Neoplasms/complications |
| مستخلص: | Objectives: To investigate the frequency of azoospermia factor (AZF) deletions in Dutch patients with testicular germ cell tumors (TGCTs). Reduced fertility is associated with TGCTs and reduced fertility and TGCTs might share genetic risk factors according to the testicular dysgenesis hypothesis. Up to 8% of infertility and reduced fertility in the general male population can be explained by the presence of constitutional deletions of part of the long arm of the Y chromosome (Yq11), referred to as the AZF region. Methods: In 112 patients with TGCT, screening for constitutional deletions in the AZF region was performed by multiplex polymerase chain reaction analysis in DNA extracted from peripheral blood lymphocytes. A set of 24 primer pairs, of which 20 primer pairs are homologous to previously identified and mapped sequenced tag sites within the AZF region were used. Results: No deletions in the Yq11 region were detected in any of the 112 patients. Conclusions: Large Y chromosome microdeletions in the AZF region are not a major contributor to the development of TGCT and TGCT-associated reduced fertility. |
| المشرفين على المادة: | 0 (Seminal Plasma Proteins) |
| تواريخ الأحداث: | Date Created: 20050126 Date Completed: 20050919 Latest Revision: 20111214 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.urology.2004.09.022 |
| PMID: | 15667903 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1527-9995 |
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| DOI: | 10.1016/j.urology.2004.09.022 |